SLYA_YERPE
ID SLYA_YERPE Reviewed; 143 AA.
AC P69988; Q0WEE8; Q66A44; Q9AM39;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
DE AltName: Full=Regulator of virulence protein A;
DE AltName: Full=Transcriptional regulator for cryptic hemolysin;
GN Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; Synonyms=rovA;
GN OrderedLocusNames=YPO2374, y1961, YP_2160;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Transcription regulator that can specifically activate or
CC repress expression of target genes. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC Rule:MF_01819}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL590842; CAL21002.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85527.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62368.1; -; Genomic_DNA.
DR PIR; AG0289; AG0289.
DR RefSeq; WP_002210955.1; NZ_WUCM01000049.1.
DR RefSeq; YP_002347340.1; NC_003143.1.
DR AlphaFoldDB; P69988; -.
DR SMR; P69988; -.
DR STRING; 214092.YPO2374; -.
DR PaxDb; P69988; -.
DR DNASU; 1146908; -.
DR EnsemblBacteria; AAM85527; AAM85527; y1961.
DR EnsemblBacteria; AAS62368; AAS62368; YP_2160.
DR GeneID; 66841281; -.
DR KEGG; ype:YPO2374; -.
DR KEGG; ypk:y1961; -.
DR KEGG; ypm:YP_2160; -.
DR PATRIC; fig|1028802.3.peg.1952; -.
DR eggNOG; COG1846; Bacteria.
DR HOGENOM; CLU_083287_18_2_6; -.
DR OMA; CSNDRRA; -.
DR PHI-base; PHI:6114; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01819; HTH_type_SlyA; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR023071; Tscrpt_reg_SlyA.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR PRINTS; PR00598; HTHMARR.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..143
FT /note="Transcriptional regulator SlyA"
FT /id="PRO_0000054398"
FT DOMAIN 2..135
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT DNA_BIND 49..72
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ SEQUENCE 143 AA; 16170 MW; 62485065D1F5A451 CRC64;
MESTLGSDLA RLVRVWRALI DHRLKPLELT QTHWVTLYNI NRLPPEQSQI QLAKAIGIEQ
PSLVRTLDQL EEKGLITRHT CANDRRAKRI KLTEQSSPII EQVDGVICST RKEILGGISS
DEIAVLSGLI DKLEKNIIQL QTK
