ID   SLYA_YERPY              Reviewed;         143 AA.
AC   B1JJ73;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
GN   Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; OrderedLocusNames=YPK_1876;
OS   Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YPIII;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription regulator that can specifically activate or
CC       repress expression of target genes. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01819}.
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DR   EMBL; CP000950; ACA68167.1; -; Genomic_DNA.
DR   RefSeq; WP_002210955.1; NZ_CP009792.1.
DR   PDB; 4AIH; X-ray; 2.40 A; A/B/C/D/E/F=1-143.
DR   PDB; 4AIJ; X-ray; 2.05 A; A/B=1-143.
DR   PDB; 4AIK; X-ray; 1.85 A; A/B=1-143.
DR   PDBsum; 4AIH; -.
DR   PDBsum; 4AIJ; -.
DR   PDBsum; 4AIK; -.
DR   AlphaFoldDB; B1JJ73; -.
DR   SMR; B1JJ73; -.
DR   EnsemblBacteria; ACA68167; ACA68167; YPK_1876.
DR   GeneID; 66841281; -.
DR   KEGG; ypy:YPK_1876; -.
DR   PATRIC; fig|502800.11.peg.2546; -.
DR   OMA; CSNDRRA; -.
DR   GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IPI:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IPI:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:CollecTF.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CollecTF.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01819; HTH_type_SlyA; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR023071; Tscrpt_reg_SlyA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..143
FT                   /note="Transcriptional regulator SlyA"
FT                   /id="PRO_1000188020"
FT   DOMAIN          2..135
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   DNA_BIND        49..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   HELIX           5..23
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           25..27
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           31..42
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           49..56
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           60..72
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   STRAND          75..80
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   STRAND          88..92
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           94..96
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           97..114
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   TURN            115..117
FT                   /evidence="ECO:0007829|PDB:4AIK"
FT   HELIX           120..139
FT                   /evidence="ECO:0007829|PDB:4AIK"
SQ   SEQUENCE   143 AA;  16170 MW;  62485065D1F5A451 CRC64;
     MESTLGSDLA RLVRVWRALI DHRLKPLELT QTHWVTLYNI NRLPPEQSQI QLAKAIGIEQ
     PSLVRTLDQL EEKGLITRHT CANDRRAKRI KLTEQSSPII EQVDGVICST RKEILGGISS
     DEIAVLSGLI DKLEKNIIQL QTK