BIG1_CANAL
ID BIG1_CANAL Reviewed; 322 AA.
AC Q59WG7; A0A1D8PF39;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Protein BIG1;
DE Flags: Precursor;
GN Name=BIG1; OrderedLocusNames=CAALFM_C110830WA;
GN ORFNames=CaO19.2334, CaO19.9870;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RX PubMed=16552067; DOI=10.1128/iai.74.4.2373-2381.2006;
RA Umeyama T., Kaneko A., Watanabe H., Hirai A., Uehara Y., Niimi M.,
RA Azuma M.;
RT "Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis,
RT filamentation, adhesion, and virulence in Candida albicans.";
RL Infect. Immun. 74:2373-2381(2006).
CC -!- FUNCTION: Required for normal beta-1,6-glucan synthesis, for hyphal
CC morphogenesis, adhesion and virulence. {ECO:0000269|PubMed:16552067}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16552067}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:16552067}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:16552067}.
CC -!- MISCELLANEOUS: Present with 3460 molecules/cell in log phase SD medium.
CC -!- SIMILARITY: Belongs to the BIG1 family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26710.1; -; Genomic_DNA.
DR RefSeq; XP_713939.1; XM_708846.2.
DR AlphaFoldDB; Q59WG7; -.
DR STRING; 237561.Q59WG7; -.
DR GeneID; 3644434; -.
DR KEGG; cal:CAALFM_C110830WA; -.
DR CGD; CAL0000189708; BIG1.
DR VEuPathDB; FungiDB:C1_10830W_A; -.
DR eggNOG; ENOG502RXHV; Eukaryota.
DR HOGENOM; CLU_067894_0_0_1; -.
DR InParanoid; Q59WG7; -.
DR OrthoDB; 1522306at2759; -.
DR PHI-base; PHI:2824; -.
DR PRO; PR:Q59WG7; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:CGD.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IDA:CGD.
DR GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR GO; GO:0006078; P:(1->6)-beta-D-glucan biosynthetic process; IMP:CGD.
DR GO; GO:0044406; P:adhesion of symbiont to host; IMP:CGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IGI:CGD.
DR InterPro; IPR037654; Big1.
DR PANTHER; PTHR28285; PTHR28285; 1.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Endoplasmic reticulum; Glycoprotein;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..322
FT /note="Protein BIG1"
FT /id="PRO_0000277849"
FT TOPO_DOM 17..274
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 38099 MW; A5ED46A402EEB3DC CRC64;
MRLFVLLAYI IPFILCQLTP VLVASHKLVR GLKEEINPSN TLPHNVTSVT NMLKKLITEC
SSDAYLLINQ PGLTYADLTT EKKDNWPFLR NYLYMSSTIV GLPRVENPID LDFLEQYIIS
NCDAETINVW HDSEDEVVDY YDIRKRVIRI DLSPLSISNH DDRVKEIFEH DQLIRKILRK
LPSAHYTIIL TSLEPGIIHP VPRFLMEETP ASFEIFDDII NDPFHNREIE KNDRFHKVEP
NWNPIRDSND RYYRNKKKDE IHLFDYELWE KNEKLITTIF VMVLSLFMMK IISFFNYLKQ
KIIQKKQQKS KRGIIADDKK LD
