ID   BIG1_CANGA              Reviewed;         319 AA.
AC   Q6FKH5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Protein BIG1;
DE   Flags: Precursor;
GN   Name=BIG1; OrderedLocusNames=CAGL0L11528g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for normal beta-1,6-glucan synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BIG1 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG62243.1; -; Genomic_DNA.
DR   RefSeq; XP_449269.1; XM_449269.1.
DR   AlphaFoldDB; Q6FKH5; -.
DR   STRING; 5478.XP_449269.1; -.
DR   EnsemblFungi; CAG62243; CAG62243; CAGL0L11528g.
DR   GeneID; 2890969; -.
DR   KEGG; cgr:CAGL0L11528g; -.
DR   CGD; CAL0135806; BIG1.
DR   VEuPathDB; FungiDB:CAGL0L11528g; -.
DR   eggNOG; ENOG502RXHV; Eukaryota.
DR   HOGENOM; CLU_067894_0_0_1; -.
DR   InParanoid; Q6FKH5; -.
DR   OMA; PNWNPIR; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   InterPro; IPR037654; Big1.
DR   PANTHER; PTHR28285; PTHR28285; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Glycoprotein;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..319
FT                   /note="Protein BIG1"
FT                   /id="PRO_0000277850"
FT   TOPO_DOM        19..269
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          297..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  35559 MW;  AE37CC11E92808DA CRC64;
     MCGLIGIIIG LLTRVALASS LDVGTSPAIL FSTRLSEGIL EYYDMFDSGA VVPREDFNTV
     CKTLISHCNS DAVVFVNQPG LSLGDLSEYA DQFQYLSSYV RHSSSAMNIE RVSVSQDDQE
     SQFESLVRYA MDTCNIYEKV VIEPYEADTY KAYIDAEKKV ILIELPEFLN TQNETDRMAL
     ISSNDNRLRN ILGQLPSPDI SVIYTSFQPS NLAADEFAEI LPAAFDVFDK NAAVERNIRL
     KDATRPGFIN YRPKFGDFNS ISQIKLDKQF LEENLGLLSA ILVSTILYLF GQRLSSHSKS
     QNTTSNSAKN TTKKAERGN