SL_CROVE
ID SL_CROVE Reviewed; 12 AA.
AC C0HL88;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 25-APR-2018, sequence version 1.
DT 10-FEB-2021, entry version 5.
DE RecName: Full=Snaclec uracolectin {ECO:0000303|Ref.1};
DE Flags: Fragment;
OS Crotalus vegrandis (Uracoan rattlesnake) (Crotalus durissus vegrandis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=184545 {ECO:0000303|Ref.1};
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom {ECO:0000303|Ref.1};
RA Giron M.E., Ramos M.I., Cantillo A.C., Oramas J.A., Sanchez E.E.,
RA Jimenez J.C., Suntravat M., Navarrete L.F., Rodriguez-Acosta A.;
RT "Haemostatic and biological activities of the Uracoan rattlesnake (Crotalus
RT vegrandis Klauber 1941) venom: isolation of a new snalecs-like uracolectin
RT with coagulent activity.";
RL Saber 32:22-33(2020).
CC -!- FUNCTION: Inhibits coagulant activity in human plasma, possibly by
CC interfering with one step of hemostasis (modulation of platelet
CC aggregation, or coagulation cascade, for example) (Ref.1). Does not
CC show fibrinogen-clotting activity and does not inhibit ADP-induced
CC platelet aggregation (Ref.1). Also does not show hemorrhagic activity
CC in mice (Ref.1). {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hemostasis impairing toxin; Secreted; Toxin.
FT CHAIN 1..>12
FT /note="Snaclec uracolectin"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000443946"
FT UNSURE 2
FT /note="L or G"
FT /evidence="ECO:0000269|Ref.1"
FT NON_TER 12
FT /evidence="ECO:0000303|Ref.1"
SQ SEQUENCE 12 AA; 1334 MW; 3C72352311A5A378 CRC64;
DLPSGWSSYE GH