SM20_SCHMA
ID SM20_SCHMA Reviewed; 154 AA.
AC P15845;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=20 kDa calcium-binding protein;
DE AltName: Full=Antigen SM20;
GN Name=SM20;
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Stewart T.J., Smith A.L., Havercroft J.C.;
RL Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 65-154.
RC STRAIN=Puerto Rican;
RX PubMed=2325706; DOI=10.1016/0166-6851(90)90024-g;
RA Havercroft J.C., Huggins M.C., Dunne D.W., Taylor D.W.;
RT "Characterisation of Sm20, a 20-kilodalton calcium-binding protein of
RT Schistosoma mansoni.";
RL Mol. Biochem. Parasitol. 38:211-220(1990).
CC -!- FUNCTION: Calcium-binding protein.
CC -!- SUBCELLULAR LOCATION: Tegument membrane. Note=Associated with the
CC tegumental membrane.
CC -!- DEVELOPMENTAL STAGE: SM20 is expressed in schistosomula and adult
CC worms, but not in eggs.
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DR EMBL; M94045; AAA29921.1; -; mRNA.
DR EMBL; M28888; AAA29926.1; -; mRNA.
DR PIR; A44977; A44977.
DR AlphaFoldDB; P15845; -.
DR SMR; P15845; -.
DR STRING; 6183.Smp_005350.1; -.
DR eggNOG; KOG0027; Eukaryota.
DR HOGENOM; CLU_542212_0_0_1; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Membrane; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..154
FT /note="20 kDa calcium-binding protein"
FT /id="PRO_0000073734"
FT DOMAIN 13..48
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 49..84
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 86..121
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 122..154
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 101
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 105
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 110
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 135
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 137
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 139
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 146
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 154 AA; 17894 MW; 36A6694780BDA2B2 CRC64;
MAFKIDDFTI QEDQVKIAKD VFKRFDKRGQ EKISTTDLGP AFRALNLTVK PDTLKEWADQ
VDDDATGFID FNGFLICYGK KLQEDQDERD LRDAFRVLDK NKRGEIDVED LRWILKGLGD
DLTEEEIDDM IRDTDTDGSG FVDFDEFYKL MTSE
