SM21_SCHMA
ID SM21_SCHMA Reviewed; 184 AA.
AC P32070; G4VA24;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Antigen Sm21.7;
DE AltName: Full=Tegumental-allergen-like protein-2 {ECO:0000303|PubMed:22509417};
DE Short=SmTAL1 {ECO:0000303|PubMed:22509417};
DE Short=TAL1 {ECO:0000303|PubMed:22509417};
GN Name=SM21.7; Synonyms=SM24;
GN ORFNames=Smp_086480 {ECO:0000303|PubMed:22253936};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Puerto Rican;
RX PubMed=1371327; DOI=10.1016/0166-6851(92)90218-9;
RA Francis P., Bickle Q.D.;
RT "Cloning of a 21.7-kDa vaccine-dominant antigen gene of Schistosoma mansoni
RT reveals an EF hand-like motif.";
RL Mol. Biochem. Parasitol. 50:215-224(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Egyptian;
RA Saber M.A.;
RL Thesis (1995), Theodor Bilharz Research Institute / Cairo, Egypt.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican;
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [4]
RP NOMENCLATURE.
RX PubMed=22509417; DOI=10.1371/journal.pntd.0001593;
RA Fitzsimmons C.M., Jones F.M., Stearn A., Chalmers I.W., Hoffmann K.F.,
RA Wawrzyniak J., Wilson S., Kabatereine N.B., Dunne D.W.;
RT "The Schistosoma mansoni tegumental-allergen-like (TAL) protein family:
RT influence of developmental expression on human IgE responses.";
RL PLoS Negl. Trop. Dis. 6:1593-1593(2012).
CC -!- DEVELOPMENTAL STAGE: Occurs in similar relative abundances in infected
CC hepatopancreas, schistosomula and adults.
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DR EMBL; M67506; AAA29923.1; -; mRNA.
DR EMBL; U30663; AAA74050.1; -; mRNA.
DR EMBL; HE601624; CCD76401.1; -; Genomic_DNA.
DR PIR; A45630; A45630.
DR RefSeq; XP_018649273.1; XM_018794907.1.
DR AlphaFoldDB; P32070; -.
DR SMR; P32070; -.
DR EnsemblMetazoa; Smp_086480.1; Smp_086480.1; Smp_086480.
DR GeneID; 8347700; -.
DR KEGG; smm:Smp_086480; -.
DR WBParaSite; Smp_086480.1; Smp_086480.1; Smp_086480.
DR CTD; 8347700; -.
DR HOGENOM; CLU_1557207_0_0_1; -.
DR OrthoDB; 1715041at2759; -.
DR PhylomeDB; P32070; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR Gene3D; 3.30.740.10; -; 1.
DR InterPro; IPR037177; DLC_sf.
DR InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF01221; Dynein_light; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR SMART; SM01375; Dynein_light; 1.
DR SMART; SM00054; EFh; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF54648; SSF54648; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome.
FT CHAIN 1..184
FT /note="Antigen Sm21.7"
FT /id="PRO_0000073857"
FT DOMAIN 37..72
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 184 AA; 21689 MW; 8ADEA7342667E9EB CRC64;
MDSPMEKFIQ TYLTLLRDGD ETVETSKLSE SCRKEKLDMK QVNEWIALFD VDKDQKITFE
EFCRGLGLKQ NEMRIERNHI KTVQSGREQS LPEGVSIIAS TMPKPKQVEV TQLFKDIYNE
VKKDPDMNKV VKTFKSELER RYGRVWQVNA VTHSYWASFS HEPFQSIQFQ YDNKIILAWR
TPSN
