ID   SM25_SCHMA              Reviewed;         182 AA.
AC   P23126;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Antigenic integral membrane glycoprotein;
DE   AltName: Full=Antigen Sm25;
DE   Flags: Precursor;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=2038357; DOI=10.1016/0166-6851(91)90088-n;
RA   Omer Ali P., Jeffs S.A., Meadows H.M., Hollyer T., Owen C., Hackett F.,
RA   Smithers S.R., Simpson A.J.G.;
RT   "Structure of Sm25, an antigenic integral membrane glycoprotein of adult
RT   Schistosoma mansoni.";
RL   Mol. Biochem. Parasitol. 45:215-222(1991).
RN   [2]
RP   PALMITOYLATION AT CYS-168.
RX   PubMed=1833182; DOI=10.1002/j.1460-2075.1991.tb07822.x;
RA   Pearce E.J., Magee A.I., Smithers S.R., Simpson A.J.G.;
RT   "Sm25, a major schistosome tegumental glycoprotein, is dependent on
RT   palmitic acid for membrane attachment.";
RL   EMBO J. 10:2741-2746(1991).
CC   -!- FUNCTION: Major antigen in the surface tegument.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Cell membrane; Lipid-anchor.
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DR   EMBL; M37004; AAA29924.1; -; mRNA.
DR   AlphaFoldDB; P23126; -.
DR   PRIDE; P23126; -.
DR   HOGENOM; CLU_1483798_0_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..35
FT   CHAIN           36..182
FT                   /note="Antigenic integral membrane glycoprotein"
FT                   /id="PRO_0000022367"
FT   TRANSMEM        162..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           168
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:1833182"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
SQ   SEQUENCE   182 AA;  21649 MW;  7D26641E3EB4E488 CRC64;
     MFSFHERMKK KHVTIRVYKH ERILVFLFVL FISTTDFSTE IIMIQTINWI VWKLFIIYIS
     LDLFSLKLVN SEENSNSIIT DEDYDHYNSS LDSSNNVKHS QEAFHRNSDP DGFPEYEFLN
     ETSIEIKEEL GQELHQLQLI LDELSRRIRA TPNSANKYMK NEFLMSSCIV ITLNLFIFMY
     KS