ID   SM34_LYTPI              Reviewed;         335 AA.
AC   Q05904;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=34 kDa spicule matrix protein;
DE   AltName: Full=LSM34;
DE   Flags: Precursor;
OS   Lytechinus pictus (Painted sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7653;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=1743395; DOI=10.1016/0012-1606(91)90265-5;
RA   Livingston B.T., Shaw R., Bailey A., Wilt F.;
RT   "Characterization of a cDNA encoding a protein involved in formation of the
RT   skeleton during development of the sea urchin Lytechinus pictus.";
RL   Dev. Biol. 148:473-480(1991).
CC   -!- FUNCTION: Major matrix protein of the sea urchin embryo spicule which
CC       directs crystal growth in certain orientations and inhibit growth in
CC       others.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Embryo spicule.
CC   -!- DOMAIN: The repetitive domain may provide a calcite binding matrix.
CC   -!- SIMILARITY: Belongs to the SM50 family. {ECO:0000305}.
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DR   EMBL; X59616; CAA42179.1; -; mRNA.
DR   PIR; A43900; A43900.
DR   AlphaFoldDB; Q05904; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Repeat; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..335
FT                   /note="34 kDa spicule matrix protein"
FT                   /id="PRO_0000017562"
FT   DOMAIN          29..194
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          199..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        50..193
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   335 AA;  35426 MW;  AA032281DDB0AE97 CRC64;
     MKGLLLILAS LVAIATGQDC PAYYVRSSSG ASCYRYFNIR VLHRMASEFC EMVTPCGNGP
     SRMGALASIS SPIENHEVYR MVASFSQDNQ MENEAWLGWN TQSPRFWEDG TPAYPNGFAG
     FHQSGSYTSW PSWRPGMPTS GWPVNPANPW TPPPGRAPVM KGQHVTPQQP GQRPNLGPEW
     DLVEATAMRA FVCEVAAGQN IPPGQQPGFG GQQPGFGGRQ PGFGGQQPGF GQQPGFGGRQ
     PGFGGRQPGF GGQQPGFGGQ QPGFGGQQPG FGGQQPGFGG QQPGFGGQQP GFGGQQPGFG
     GGPQRPGMGG QPNSPNPRFN RPRMLQEAET DVTGS