ID   SM41_HEMPU              Reviewed;         407 AA.
AC   Q26264;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=41 kDa spicule matrix protein;
DE   AltName: Full=HPSMC;
DE   AltName: Full=HSM41;
DE   Flags: Precursor;
OS   Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Hemicentrotus.
OX   NCBI_TaxID=7650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1445780;
RA   Katoh-Fukui Y., Noce T., Ueda T., Fujiwara Y., Hashimoto N., Tanaka S.,
RA   Higashinakagawa T.;
RT   "Isolation and characterization of cDNA encoding a spicule matrix protein
RT   in Hemicentrotus pulcherrimus micromeres.";
RL   Int. J. Dev. Biol. 36:353-361(1992).
CC   -!- FUNCTION: Major matrix protein of the sea urchin embryo spicule which
CC       directs crystal growth in certain orientations and inhibit growth in
CC       others. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the micromere/primary
CC       mesenchyme cells (PMC) lineage.
CC   -!- DEVELOPMENTAL STAGE: Appears in gastrulae and remains at a similar
CC       level until the pluteus stage.
CC   -!- DOMAIN: The repetitive domain may provide a calcite binding matrix.
CC   -!- SIMILARITY: Belongs to the SM50 family. {ECO:0000305}.
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DR   EMBL; S48755; AAB24285.1; -; mRNA.
DR   AlphaFoldDB; Q26264; -.
DR   SMR; Q26264; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR009765; Pericardin-like_rpt.
DR   Pfam; PF07054; Pericardin_rpt; 6.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..407
FT                   /note="41 kDa spicule matrix protein"
FT                   /id="PRO_0000017563"
FT   DOMAIN          29..160
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          143..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..391
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  42382 MW;  5A5397C46B80F6B5 CRC64;
     MKGVLFIVAS LVAFATGQDC PAYYVRSQSG QSCYRYFNMR VPYRMASEFC EMVTPCGNGP
     AKMGALASVS SPQENMEIYQ LVAGFSQDNQ MENEVWLGWN SMSPFFWEDG TPAYPNGFAA
     FSSSGMAPPR PGAPPSRAWP VNPQNPMSGP PGRAPVMKRQ NPPVRPGQGG RQIPQGVGPQ
     WEAVEVTAMR AFVCEVPAGR NVPIGQQPGM GQGFGNQQPG FGNQPGMGGR QPGFGNQPGM
     GGRQPGFGNQ PGMGGRQPGF GNQPGVGGRQ PGFGNQPGMG GRQPGFGNQP GVGGRQPGFG
     NQPGMGGQQP GVGGRQPGFG NQPGMGGNQP GMGGQQPGMG GRQPGVGGRQ PGMGGQQPGM
     GGRQPGMGGQ QPNNPNNPNN PNNPNNPNNP NPRFNRPRML QEADALA