ID   SMA2_ASHGO              Reviewed;         385 AA.
AC   Q756X9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Spore membrane assembly protein 2;
GN   Name=SMA2; OrderedLocusNames=AER135W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in spore and ascus formation. Required for the
CC       efficient assembly of the precursors of the prospore membrane to a
CC       continuous prospore membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Prospore membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMA2 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52818.1; -; Genomic_DNA.
DR   RefSeq; NP_984994.1; NM_210348.1.
DR   AlphaFoldDB; Q756X9; -.
DR   STRING; 33169.AAS52818; -.
DR   EnsemblFungi; AAS52818; AAS52818; AGOS_AER135W.
DR   GeneID; 4621200; -.
DR   KEGG; ago:AGOS_AER135W; -.
DR   eggNOG; ENOG502QW7F; Eukaryota.
DR   HOGENOM; CLU_776604_0_0_1; -.
DR   InParanoid; Q756X9; -.
DR   OMA; RDLPICT; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005628; C:prospore membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Sporulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Spore membrane assembly protein 2"
FT                   /id="PRO_0000324500"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..231
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        302..322
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        344..385
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   385 AA;  43711 MW;  FB5936170F8C0D40 CRC64;
     MGSRLLQFQS YGKWFMLLSL ATAICLLHLP SYSCTYSRDL PICTPQVSFQ LTNTTPTATL
     FLSTVKEVSM LLSYVAIDLG WNVNFPKPND YDTSNLVNTF DPSNKYHVNL FGYCKWQPLS
     NKATWYCMDN PNGLDIISMI VRDLGAQLGV LSHTNTKILS DSLWILYRSI FDSFYKFVHD
     DDYRADKVAS FLQSLQQGGP LPSVDQFKTV TLLLKCFEKL TNAIQVTELC SFALIIIAIA
     LATVACVMDI LAAREEKHSA TSDKLPKALF FKQITLKLSY AVVTCSLFYQ IGMAVYFLAL
     FSIRYPYDYK VKVMTFNPDT GYWLSVLRFV MEFWFAVACY IGLSLSRRRP SKEVDDLDWK
     DEEQTPDSGE TAICVSTRGS TRIQV