ID   SMA2_KLULA              Reviewed;         378 AA.
AC   Q6CWD4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Spore membrane assembly protein 2;
GN   Name=SMA2; OrderedLocusNames=KLLA0B04972g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in spore and ascus formation. Required for the
CC       efficient assembly of the precursors of the prospore membrane to a
CC       continuous prospore membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Prospore membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMA2 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02148.1; -; Genomic_DNA.
DR   RefSeq; XP_451755.1; XM_451755.1.
DR   AlphaFoldDB; Q6CWD4; -.
DR   STRING; 28985.XP_451755.1; -.
DR   EnsemblFungi; CAH02148; CAH02148; KLLA0_B04972g.
DR   GeneID; 2897240; -.
DR   KEGG; kla:KLLA0_B04972g; -.
DR   eggNOG; ENOG502QW7F; Eukaryota.
DR   HOGENOM; CLU_776604_0_0_1; -.
DR   InParanoid; Q6CWD4; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005628; C:prospore membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Sporulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..378
FT                   /note="Spore membrane assembly protein 2"
FT                   /id="PRO_0000324502"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..217
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..267
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..302
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        324..378
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          344..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  43806 MW;  38D25BF73483FE45 CRC64;
     MRFKYISFII LISFSLLVWF SHLSNFTCTS SANLPICMPQ YVFHFKDDTP TSKVLFSTVK
     EFFSLLSFFT LDFNWGIDLS ELQDRYNQSN LINIFHPSNT YYVNAFGYCK HQAQDEKLNH
     YCIDNTNGLN IISVLIRDLG FQFGVLSETN VKITGDSFWI IYQTLINSFN KFLEDDKRGN
     TLLKMITPND PNEMEQWKTR LWLINIYDAV NVVLKWTVVA NCILASLCLM LLLFWMWMQI
     EHKKTQSPIK QLNWNINSIC SITRCLSICN ATITFIYILH ILLLTFMINC FRYKRLQIIH
     ASLGTGAWFH IARFFVELIF AVLCFKWMTP HSAMSASVMS ETQSTAVEDE EEKDTEDNYS
     ALNPASGTTA VDGFLLTV