ID   SMA2_VANPO              Reviewed;         362 AA.
AC   A7TMB7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Spore membrane assembly protein 2;
GN   Name=SMA2; ORFNames=Kpol_520p34;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in spore and ascus formation. Required for the
CC       efficient assembly of the precursors of the prospore membrane to a
CC       continuous prospore membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Prospore membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Localizes to prospore membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMA2 family. {ECO:0000305}.
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DR   EMBL; DS480421; EDO16611.1; -; Genomic_DNA.
DR   RefSeq; XP_001644469.1; XM_001644419.1.
DR   AlphaFoldDB; A7TMB7; -.
DR   STRING; 436907.A7TMB7; -.
DR   EnsemblFungi; EDO16611; EDO16611; Kpol_520p34.
DR   GeneID; 5544774; -.
DR   KEGG; vpo:Kpol_520p34; -.
DR   eggNOG; ENOG502QW7F; Eukaryota.
DR   HOGENOM; CLU_776604_0_0_1; -.
DR   InParanoid; A7TMB7; -.
DR   OMA; TIDMGWS; -.
DR   OrthoDB; 1014342at2759; -.
DR   PhylomeDB; A7TMB7; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005628; C:prospore membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Sporulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..362
FT                   /note="Spore membrane assembly protein 2"
FT                   /id="PRO_0000324503"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..232
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..267
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..312
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        334..362
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   362 AA;  40963 MW;  FDCA64B73C649B82 CRC64;
     MIFLKRFIVW TFLFIVTLIQ LLLYLPDFSC ISKNGGLPIC TSQFNFAIVD SSHITHDFIT
     SIRELLRLLS YLTIDMGWSS GLPAPDAYND ENLVDTFHLN NIYKVNYFGY CKKNGKQKEY
     CTSNHSSGMD ILALLVRDVG IQLGKLSSAY ENNTEILGES LVFTYELSLS SLHTFIKGDR
     QRGNILPKIV TNQGNEQTDL EYSSSKAYDK GVSLAYGLML FNEIMYFIHI FEITISVHCF
     LNVILFGFAL VWGKKQILLP TLLKITSSLL LVFASISFSG NLLYLLLLKM LEPDPTGITT
     TGWEMLEVKA GSGFIITCIR VGIQWIFLPV AFITSNHYIQ PKKQQTKIDE LKSDDESTVK
     QV