ID   SMA2_YEAS7              Reviewed;         369 AA.
AC   A6ZLZ9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Spore membrane assembly protein 2;
GN   Name=SMA2; ORFNames=SCY_4111;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Involved in spore and ascus formation. Required for the
CC       efficient assembly of the precursors of the prospore membrane to a
CC       continuous prospore membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Prospore membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
CC       Note=Localizes to prospore membrane, and accumulates in the endoplasmic
CC       reticulum in vegetative and sporulating ERV14-deleted cells.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMA2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFW02000020; EDN64329.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZLZ9; -.
DR   EnsemblFungi; EDN64329; EDN64329; SCY_4111.
DR   HOGENOM; CLU_776604_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005628; C:prospore membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Sporulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..369
FT                   /note="Spore membrane assembly protein 2"
FT                   /id="PRO_0000324504"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..220
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..319
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          348..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  40826 MW;  ACAD49EA08E734BC CRC64;
     MLFPKRLIVW GVLLILSLSQ FVLYLPATTC TNSKGLRLCA PQFTITVIGG SSTANEFIAS
     VREFLRLISY LTIDMGWSNE FTDPSVYEDE NLVDTFQPDK VFELNYFGFC KRSNKSKVYC
     TSNENYGMDV LEVLVRDVGI QLGNISTTRS NETKKFGDSL VLTYRLALTS IRDFLKHDKH
     TGNALSKALI GSPDPNVKGA SPTKNYLKGV NLAFILMMFN GMVFYFAVLE IIVGFLSICV
     VSAFGGALSV GKRHRLFPIL LKSSSSILVV IATLTILCNI VYLIALKTLE PEEVTDVGSD
     NAAVHTTGWE LLKVNVGSGF IMGLARYAIQ WVLLVLAFLA ANHYKAKPKK SDKYTEDTSN
     SPSPDLMEK