SMA9_CAEEL
ID SMA9_CAEEL Reviewed; 2242 AA.
AC Q7JM44; A0A5T0BWQ3; A0A5T0C5A1; A0A679M2I6; B5U8M3; G5ED62; Q22190; Q7JM42;
AC Q7JM43; Q7JM45; Q7JM48;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2019, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Transcription factor sma-9 {ECO:0000305};
GN Name=sma-9 {ECO:0000312|WormBase:T05A10.1d};
GN ORFNames=T05A10.1 {ECO:0000312|WormBase:T05A10.1d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAQ94962.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H), FUNCTION, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, AND MUTAGENESIS OF 1235-ARG--ASN-2242.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAQ94962.1};
RX PubMed=14627718; DOI=10.1242/dev.00863;
RA Liang J., Lints R., Foehr M.L., Tokarz R., Yu L., Emmons S.W., Liu J.,
RA Savage-Dunn C.;
RT "The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell
RT type-specific responses to DBL-1 BMP-related signaling.";
RL Development 130:6453-6464(2003).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF 55-GLN--ASN-2242 AND 2226-GLN--ASN-2242.
RX PubMed=16790477; DOI=10.1242/dev.02476;
RA Foehr M.L., Lindy A.S., Fairbank R.C., Amin N.M., Xu M., Yanowitz J.,
RA Fire A.Z., Liu J.;
RT "An antagonistic role for the C. elegans Schnurri homolog SMA-9 in
RT modulating TGFbeta signaling during mesodermal patterning.";
RL Development 133:2887-2896(2006).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=17397820; DOI=10.1016/j.ydbio.2007.02.038;
RA Liang J., Yu L., Yin J., Savage-Dunn C.;
RT "Transcriptional repressor and activator activities of SMA-9 contribute
RT differentially to BMP-related signaling outputs.";
RL Dev. Biol. 305:714-725(2007).
RN [5] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF 2226-GLN--ASN-2242.
RX PubMed=18036582; DOI=10.1016/j.ydbio.2007.10.027;
RA Foehr M.L., Liu J.;
RT "Dorsoventral patterning of the C. elegans postembryonic mesoderm requires
RT both LIN-12/Notch and TGFbeta signaling.";
RL Dev. Biol. 313:256-266(2008).
RN [6] {ECO:0000305}
RP FUNCTION (ISOFORM H), AND DEVELOPMENTAL STAGE (ISOFORM H).
RX PubMed=20565799; DOI=10.1186/1471-2199-11-46;
RA Yin J., Yu L., Savage-Dunn C.;
RT "Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri
RT generates a short transcript that provides tissue-specific function in BMP
RT signaling.";
RL BMC Mol. Biol. 11:46-46(2010).
RN [7] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25407930; DOI=10.1007/s12035-014-8988-y;
RA Haque R., Nazir A.;
RT "SMAD Transcription Factor, Sma-9, Attunes TGF-beta Signaling Cascade
RT Towards Modulating Amyloid Beta Aggregation and Associated Outcome in
RT Transgenic C. elegans.";
RL Mol. Neurobiol. 53:109-119(2016).
RN [8] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF 2226-GLN--ASN-2242.
RX PubMed=29155044; DOI=10.1016/j.ydbio.2017.11.008;
RA Shen Q., Toulabi L.B., Shi H., Nicklow E.E., Liu J.;
RT "The forkhead transcription factor UNC-130/FOXD integrates both BMP and
RT Notch signaling to regulate dorsoventral patterning of the C. elegans
RT postembryonic mesoderm.";
RL Dev. Biol. 433:75-83(2018).
CC -!- FUNCTION: Transcription factor, probably acting as a transcriptional
CC activator and repressor, involved in the TGF-beta-like dbl-1 signaling
CC pathway (PubMed:14627718, PubMed:17397820). Plays a role in regulation
CC of body size, and patterning of male-specific genital sensilla (simple
CC sense organs), known as rays, and mating-associated structures,
CC spicules (PubMed:14627718). Required for the dorsoventral patterning of
CC the postembryonic mesodermal lineage (M lineage), acting by
CC antagonizing the TGF-beta-like dbl-1 signaling pathway, in part by
CC repressing expression of transcription factor unc-130 (PubMed:16790477,
CC PubMed:18036582, PubMed:29155044). Involved in egg-laying, perhaps via
CC modulation of cholinergic neurotransmission (PubMed:25407930). May play
CC a role in modulating lifespan and in responses to proteotoxic stress
CC (PubMed:25407930). {ECO:0000269|PubMed:14627718,
CC ECO:0000269|PubMed:16790477, ECO:0000269|PubMed:17397820,
CC ECO:0000269|PubMed:18036582, ECO:0000269|PubMed:25407930,
CC ECO:0000269|PubMed:29155044}.
CC -!- FUNCTION: [Isoform h]: Transcription factor, probably acting as a
CC transcriptional activator (PubMed:17397820). Required for patterning of
CC male-specific genital sensilla (simple sense organs), known as rays
CC (PubMed:20565799). Dispensable for regulation of body size
CC (PubMed:20565799). {ECO:0000269|PubMed:17397820,
CC ECO:0000269|PubMed:20565799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14627718}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=11;
CC Name=d {ECO:0000312|WormBase:T05A10.1d};
CC IsoId=Q7JM44-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:T05A10.1a};
CC IsoId=Q7JM44-4; Sequence=VSP_061084;
CC Name=b {ECO:0000312|WormBase:T05A10.1b};
CC IsoId=Q7JM44-10; Sequence=VSP_061083, VSP_061085, VSP_061086,
CC VSP_061087;
CC Name=c {ECO:0000312|WormBase:T05A10.1c};
CC IsoId=Q7JM44-3; Sequence=VSP_061082;
CC Name=e {ECO:0000312|WormBase:T05A10.1e};
CC IsoId=Q7JM44-2; Sequence=VSP_061093;
CC Name=f {ECO:0000312|WormBase:T05A10.1f};
CC IsoId=Q7JM44-6; Sequence=VSP_061091;
CC Name=g {ECO:0000312|WormBase:T05A10.1g};
CC IsoId=Q7JM44-7; Sequence=VSP_061090, VSP_061095;
CC Name=h {ECO:0000312|WormBase:T05A10.1h};
CC IsoId=Q7JM44-11; Sequence=VSP_061081, VSP_061092, VSP_061094;
CC Name=i {ECO:0000312|WormBase:T05A10.1i};
CC IsoId=Q7JM44-8; Sequence=VSP_061085, VSP_061090, VSP_061095;
CC Name=j {ECO:0000312|WormBase:T05A10.1j};
CC IsoId=Q7JM44-9; Sequence=VSP_061085, VSP_061088, VSP_061089;
CC Name=m {ECO:0000312|WormBase:T05A10.1m};
CC IsoId=Q7JM44-5; Sequence=VSP_061083, VSP_061084, VSP_061093;
CC -!- TISSUE SPECIFICITY: Expressed in the ventral nerve cord (VNC), pharynx,
CC intestine and seam cells (at protein level).
CC {ECO:0000269|PubMed:14627718}.
CC -!- DEVELOPMENTAL STAGE: Expressed from larval stage L1 to adult stages but
CC not during embryonic development. {ECO:0000269|PubMed:14627718}.
CC -!- DEVELOPMENTAL STAGE: [Isoform h]: Expressed at larval L1 and L3 stages
CC and in adulthood. {ECO:0000269|PubMed:20565799}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes a reduction in
CC acetylcholine (ACh) content, altered sensitivity to Aldicarb, a potent
CC acetylcholinesterase (AChE) inhibitor, reduced expression of vesicular
CC acetylcholine transporter unc-17 and elevated levels of reactive oxygen
CC species (PubMed:25407930). Knockdown inhibits nuclear localization of
CC transcription factor daf-16 (PubMed:25407930).
CC {ECO:0000269|PubMed:25407930}.
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DR EMBL; AY390550; AAQ94962.1; -; mRNA.
DR EMBL; BX284606; CAA92133.3; -; Genomic_DNA.
DR EMBL; BX284606; CAD44152.2; -; Genomic_DNA.
DR EMBL; BX284606; CAF31486.1; -; Genomic_DNA.
DR EMBL; BX284606; CAF31487.1; -; Genomic_DNA.
DR EMBL; BX284606; CAF31490.2; -; Genomic_DNA.
DR EMBL; BX284606; CAF31491.2; -; Genomic_DNA.
DR EMBL; BX284606; CAF31492.2; -; Genomic_DNA.
DR EMBL; BX284606; CAF31493.2; -; Genomic_DNA.
DR EMBL; BX284606; CAR64679.2; -; Genomic_DNA.
DR EMBL; BX284606; CEN20182.1; -; Genomic_DNA.
DR EMBL; BX284606; CEN20183.1; -; Genomic_DNA.
DR PIR; T24490; T24490.
DR RefSeq; NP_001024877.1; NM_001029706.4.
DR RefSeq; NP_001024878.1; NM_001029707.5.
DR RefSeq; NP_001024879.1; NM_001029708.2.
DR RefSeq; NP_001024880.1; NM_001029709.1.
DR RefSeq; NP_001024881.1; NM_001029710.3.
DR RefSeq; NP_001024882.1; NM_001029711.3.
DR RefSeq; NP_001024883.1; NM_001029712.2.
DR RefSeq; NP_001024884.1; NM_001029713.3.
DR RefSeq; NP_001129936.1; NM_001136464.2.
DR RefSeq; NP_741896.2; NM_171771.5. [Q7JM44-4]
DR RefSeq; NP_741897.2; NM_171772.3.
DR AlphaFoldDB; Q7JM44; -.
DR SMR; Q7JM44; -.
DR DIP; DIP-25468N; -.
DR IntAct; Q7JM44; 38.
DR STRING; 6239.T05A10.1m; -.
DR EnsemblMetazoa; T05A10.1a.1; T05A10.1a.1; WBGene00004862. [Q7JM44-4]
DR EnsemblMetazoa; T05A10.1b.1; T05A10.1b.1; WBGene00004862. [Q7JM44-10]
DR EnsemblMetazoa; T05A10.1c.1; T05A10.1c.1; WBGene00004862. [Q7JM44-3]
DR EnsemblMetazoa; T05A10.1c.2; T05A10.1c.2; WBGene00004862. [Q7JM44-3]
DR EnsemblMetazoa; T05A10.1d.1; T05A10.1d.1; WBGene00004862. [Q7JM44-1]
DR EnsemblMetazoa; T05A10.1e.1; T05A10.1e.1; WBGene00004862. [Q7JM44-2]
DR EnsemblMetazoa; T05A10.1f.1; T05A10.1f.1; WBGene00004862. [Q7JM44-6]
DR EnsemblMetazoa; T05A10.1g.1; T05A10.1g.1; WBGene00004862. [Q7JM44-7]
DR EnsemblMetazoa; T05A10.1h.1; T05A10.1h.1; WBGene00004862. [Q7JM44-11]
DR EnsemblMetazoa; T05A10.1h.2; T05A10.1h.2; WBGene00004862. [Q7JM44-11]
DR EnsemblMetazoa; T05A10.1i.1; T05A10.1i.1; WBGene00004862. [Q7JM44-8]
DR EnsemblMetazoa; T05A10.1j.1; T05A10.1j.1; WBGene00004862. [Q7JM44-9]
DR EnsemblMetazoa; T05A10.1j.2; T05A10.1j.2; WBGene00004862. [Q7JM44-9]
DR EnsemblMetazoa; T05A10.1j.3; T05A10.1j.3; WBGene00004862. [Q7JM44-9]
DR EnsemblMetazoa; T05A10.1j.4; T05A10.1j.4; WBGene00004862. [Q7JM44-9]
DR EnsemblMetazoa; T05A10.1m.1; T05A10.1m.1; WBGene00004862. [Q7JM44-5]
DR GeneID; 181271; -.
DR CTD; 181271; -.
DR WormBase; T05A10.1a; CE36395; WBGene00004862; sma-9.
DR WormBase; T05A10.1b; CE36396; WBGene00004862; sma-9.
DR WormBase; T05A10.1c; CE36397; WBGene00004862; sma-9.
DR WormBase; T05A10.1d; CE53674; WBGene00004862; sma-9.
DR WormBase; T05A10.1e; CE53502; WBGene00004862; sma-9.
DR WormBase; T05A10.1f; CE53550; WBGene00004862; sma-9.
DR WormBase; T05A10.1g; CE53588; WBGene00004862; sma-9.
DR WormBase; T05A10.1h; CE36402; WBGene00004862; sma-9.
DR WormBase; T05A10.1i; CE36403; WBGene00004862; sma-9.
DR WormBase; T05A10.1j; CE36404; WBGene00004862; sma-9.
DR WormBase; T05A10.1m; CE53497; WBGene00004862; sma-9.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_507387_0_0_1; -.
DR OrthoDB; 180157at2759; -.
DR SignaLink; Q7JM44; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00004862; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q7JM44; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IMP:WormBase.
DR GO; GO:0003714; F:transcription corepressor activity; IMP:WormBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0034605; P:cellular response to heat; IMP:UniProtKB.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0090597; P:nematode male tail mating organ morphogenesis; IMP:UniProtKB.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0048337; P:positive regulation of mesodermal cell fate specification; IMP:UniProtKB.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IMP:UniProtKB.
DR GO; GO:0042661; P:regulation of mesodermal cell fate specification; IMP:UniProtKB.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Coiled coil; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2242
FT /note="Transcription factor sma-9"
FT /id="PRO_0000452988"
FT ZN_FING 1447..1469
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1475..1499
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1700..1722
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1734..1760
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1790..1814
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 2111..2134
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 2143..2167
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 317..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2085..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2219..2242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..383
FT /evidence="ECO:0000255"
FT COMPBIAS 499..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2220..2242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1471
FT /note="MSHQAIGISNNFQQVQREQLNHQRLLQAQLQTNGPGSVSQQQQASQQQQQVQ
FT HVQQQQQSQQQQQQVASQQNQPQLQMNAQILQALSTPQGQNLVNMLLMQQALNAQQTDT
FT QNPQQIMQHQLAQQQAQQAQQAQQAQQARQQAEQQAQAQARHQAEQQAQQQAQQQAQAR
FT QQEQQAQLAAIQQQVTPQQFAQILHMQQQLQQQQFQQQQLQQQQLQQQQLQQQQLQQQQ
FT LQQQQLQQVLQISQAQQQAQQAQHVQSRQMQPSQQSQVQAQLQQQQQLQQQQAQQLSQQ
FT QAQQQQQLQQLQLQQFLQQQQQLHQQRAAAQQAQAQNNASQQRPSVASTPALSSTPQLN
FT DLTQTMQAQLQQQLLLQQQQAQAQQAQQAQQAQLAQQAQQQQQGQSQNRTVSQALQYIQ
FT SMQLQQRADGTPNAESQEERLAQMLNEQQQRMLQNQAREAQHRQLLISSTPAPRGGITM
FT GTPIGIARREEQPVPSTVAVTTAPAAVRTPVAVPPMKQNSNPSMNPSSTSTSASATSSH
FT QILAPSLSKPLEQPSSSKAASSGNESMSDHISRIISENEVILQGDPVIRKKRPYHRQIG
FT AQSSVDHDSNSGGSTRTSPGPKDSRMLQAASRSQSLFELSGSKHFMGSLTSGQPLLRPI
FT QAHNDPNYTPECIYCKLTFPNEAGLQAHEVVCGKKKELEKAQIAQEGNPHSALKRRHTH
FT QDATLAMHSPLAAHTPSNMPGPSEPAIKLKKDDSTELDGTSKPDALQSSSSFPRSLPKE
FT WEQHMLTLQNLAAIIPPFVQAFLAKVLQTKLTMVSSGTLTHIYENYNISPICVKQFLHF
FT ASQLTDQQLEEMTVESEKQYLENAEEYQAKGIIQALPCDNLEVTEMLKQQETIMKGQVP
FT DLLVSTQAVLHHCSGKRDNKDPSKNFVMIKLLHANGKDITEIPMKAETDLDECNARFVY
FT QMREFQKINNMNDRLIEVLKTDPAAAATPLFQVAREQSASVKFLIRQTGMVHLTIVASV
FT AKRLGMSSMQQDVPESNQIPNGIIAFDGVQIKQEPEDPPGDDDDDDDDCIIEVVDEDQK
FT QHIAMLTAAASGQDIGIGGQFQKVTQNLEPAIVNQQSIVNHGDSIVNNASIPIANNAPV
FT QIVQNGGPMQHEVVAMPVQLKLEDLRLEPQTSGDTDKPYWLVINGDIGGRPSFMTTAGM
FT TSRTHRTRNITSETYVTVPRQQPMFAVQDGTLSMYAKWNVPVHNDAETKMNLSFMGMVS
FT LRRRTGQQKFFKYTTANKDQGHYRMTHSSFWDISTKIRDRQASMSEEKTPEESVDYDAQ
FT FIERLVGGTYTNTDLQGPSNAPVTIPVLVAPEDSTSAEPSTSGQSLLMRSPRPQSPPLR
FT DIKMDLSDDDYSATDLATTCKLEPKQESFEDVKDVKRENSPDARPTVIISDDAGRIRRE
FT RFANKYISRIRPKHDQIIGGHRTDEVYVYVRGRGRGRYICDRCGIRCKKPSMLKKHIKS
FT HTD -> MLKKHIKSHTD (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_061081"
FT VAR_SEQ 1..550
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061082"
FT VAR_SEQ 1..13
FT /note="MSHQAIGISNNFQ -> MAFAPGSGGGGAPPGQQPAQMMMPQNISAETYHRL
FT N (in isoform m and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061083"
FT VAR_SEQ 420..595
FT /note="Missing (in isoform a and isoform m)"
FT /evidence="ECO:0000305"
FT /id="VSP_061084"
FT VAR_SEQ 420..527
FT /note="Missing (in isoform i, isoform b and isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_061085"
FT VAR_SEQ 780..810
FT /note="QAFLAKVLQTKLTMVSSGTLTHIYENYNISP -> SERLYRIHTKDKTPEIK
FT LVSIFGSFYFLILK (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061086"
FT VAR_SEQ 811..2242
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061087"
FT VAR_SEQ 1616..1617
FT /note="AM -> GQ (in isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_061088"
FT VAR_SEQ 1618..2242
FT /note="Missing (in isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_061089"
FT VAR_SEQ 1927..2035
FT /note="VSAVSASGSQSNVSCVSSFNNSTMSPNPTVVPQVFPTPNPSSPLESSSMQFR
FT KKAVLDSATHANDMPRTILRISEIPSSLPVNHQLHRDLSFLAHTTSRSESSITSPIV
FT -> QLQQLHYVAQSNCGSTGVSNTKSVIPIGIVLNAVQKESSFGLGNTRERHAQNNSTN
FT LGDSVQSTSQSSTCEIWVPYHICVFFKAITSLISANLKSHLINTLHLFSKFMI (in
FT isoform g and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_061090"
FT VAR_SEQ 1927..2012
FT /note="Missing (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_061091"
FT VAR_SEQ 1927..1997
FT /note="VSAVSASGSQSNVSCVSSFNNSTMSPNPTVVPQVFPTPNPSSPLESSSMQFR
FT KKAVLDSATHANDMPRTIL -> QLQQLHYVAQSNCGSTGVSNTKSVIPIGIVLNAVQK
FT ESSFGLGNTRERHAQNNSTNLGDSVQSTSQSSTSS (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_061092"
FT VAR_SEQ 1927..1959
FT /note="Missing (in isoform e and isoform m)"
FT /evidence="ECO:0000305"
FT /id="VSP_061093"
FT VAR_SEQ 1998..2242
FT /note="Missing (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_061094"
FT VAR_SEQ 2036..2242
FT /note="Missing (in isoform g and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_061095"
FT MUTAGEN 55..2242
FT /note="Missing: In cc606; lacks postembryonic mesodermal
FT lineage (M lineage) derived coelomocytes (CCs)."
FT /evidence="ECO:0000269|PubMed:16790477"
FT MUTAGEN 1235..2242
FT /note="Missing: In wk55; in larval L1 through L3 stages,
FT shows a reduced growth rate, and after L3, growth rate
FT increases to a wild-type rate and finally gives the adult
FT animals an intermediate body length. Male-specific genital
FT sensilla (simple sense organs), known as rays, fuse
FT abnormally."
FT /evidence="ECO:0000269|PubMed:14627718"
FT MUTAGEN 2226..2242
FT /note="Missing: In cc604; lacks postembryonic mesodermal
FT lineage (M lineage) derived coelomocytes (CCs). Exhibits
FT loss of dorsal, and duplication of ventral, postembryonic
FT mesodermal lineage (M lineage) descendants. On lin-12 or
FT lag-1 mutant backgrounds, dorsoventral polarity of the M
FT lineage is reversed. Transcription factor unc-130
FT ectopically expressed in all M lineage cells from the 1-M
FT stage through to the 18-M stage, whereas in wild-type only
FT expressed in ventral M lineage starting from the 8-M
FT stage."
FT /evidence="ECO:0000269|PubMed:16790477,
FT ECO:0000269|PubMed:18036582, ECO:0000269|PubMed:29155044"
SQ SEQUENCE 2242 AA; 249950 MW; BE0FC9C2F1A49EEC CRC64;
MSHQAIGISN NFQQVQREQL NHQRLLQAQL QTNGPGSVSQ QQQASQQQQQ VQHVQQQQQS
QQQQQQVASQ QNQPQLQMNA QILQALSTPQ GQNLVNMLLM QQALNAQQTD TQNPQQIMQH
QLAQQQAQQA QQAQQAQQAR QQAEQQAQAQ ARHQAEQQAQ QQAQQQAQAR QQEQQAQLAA
IQQQVTPQQF AQILHMQQQL QQQQFQQQQL QQQQLQQQQL QQQQLQQQQL QQQQLQQVLQ
ISQAQQQAQQ AQHVQSRQMQ PSQQSQVQAQ LQQQQQLQQQ QAQQLSQQQA QQQQQLQQLQ
LQQFLQQQQQ LHQQRAAAQQ AQAQNNASQQ RPSVASTPAL SSTPQLNDLT QTMQAQLQQQ
LLLQQQQAQA QQAQQAQQAQ LAQQAQQQQQ GQSQNRTVSQ ALQYIQSMQL QQRADGTPNA
ESQEERLAQM LNEQQQRMLQ NQAREAQHRQ LLISSTPAPR GGITMGTPIG IARREEQPVP
STVAVTTAPA AVRTPVAVPP MKQNSNPSMN PSSTSTSASA TSSHQILAPS LSKPLEQPSS
SKAASSGNES MSDHISRIIS ENEVILQGDP VIRKKRPYHR QIGAQSSVDH DSNSGGSTRT
SPGPKDSRML QAASRSQSLF ELSGSKHFMG SLTSGQPLLR PIQAHNDPNY TPECIYCKLT
FPNEAGLQAH EVVCGKKKEL EKAQIAQEGN PHSALKRRHT HQDATLAMHS PLAAHTPSNM
PGPSEPAIKL KKDDSTELDG TSKPDALQSS SSFPRSLPKE WEQHMLTLQN LAAIIPPFVQ
AFLAKVLQTK LTMVSSGTLT HIYENYNISP ICVKQFLHFA SQLTDQQLEE MTVESEKQYL
ENAEEYQAKG IIQALPCDNL EVTEMLKQQE TIMKGQVPDL LVSTQAVLHH CSGKRDNKDP
SKNFVMIKLL HANGKDITEI PMKAETDLDE CNARFVYQMR EFQKINNMND RLIEVLKTDP
AAAATPLFQV AREQSASVKF LIRQTGMVHL TIVASVAKRL GMSSMQQDVP ESNQIPNGII
AFDGVQIKQE PEDPPGDDDD DDDDCIIEVV DEDQKQHIAM LTAAASGQDI GIGGQFQKVT
QNLEPAIVNQ QSIVNHGDSI VNNASIPIAN NAPVQIVQNG GPMQHEVVAM PVQLKLEDLR
LEPQTSGDTD KPYWLVINGD IGGRPSFMTT AGMTSRTHRT RNITSETYVT VPRQQPMFAV
QDGTLSMYAK WNVPVHNDAE TKMNLSFMGM VSLRRRTGQQ KFFKYTTANK DQGHYRMTHS
SFWDISTKIR DRQASMSEEK TPEESVDYDA QFIERLVGGT YTNTDLQGPS NAPVTIPVLV
APEDSTSAEP STSGQSLLMR SPRPQSPPLR DIKMDLSDDD YSATDLATTC KLEPKQESFE
DVKDVKRENS PDARPTVIIS DDAGRIRRER FANKYISRIR PKHDQIIGGH RTDEVYVYVR
GRGRGRYICD RCGIRCKKPS MLKKHIKSHT DVRAFNCTAC NFSFKTKGNL TKHLSSKTHQ
RRISNIQAGN DSDGTTPSTS SMMNMDDGYH RNQPLFDDYD NNSSDEEDYD HLNRMQAEHK
FKFGQEHILF ERTAHTPPTR WCLVEAQNDH YWPSPDRRSC MSAPPVAMQR DFDDRAMTPV
SGANSPYLSQ QVHSPMSTSS QSNIILDIPN NQKSNCSSVS NVSPSNSQNF QSLSTVPTCA
SSSSNVLVPN VNFLQKDETL KCDQCDRTFR KISDLTLHQH THNIEMQQSK NRMYQCSECK
IPIRTKAQLQ KHLERNHGVH MDESVTACID PLASTQSVLG GPSTSNPRSF MCVDCDIGFR
KHGILAKHLR SKTHVMKLES LQRLPVDTLS LITKKDNGAC LNDIDTTDCE KARISLLAIV
EKLRNEADKD EQGSVVPTTS IPAPQPVALT PEMIRALANA QTPVTASMTN TPSTAQFPVG
VVSTPSVSAV SASGSQSNVS CVSSFNNSTM SPNPTVVPQV FPTPNPSSPL ESSSMQFRKK
AVLDSATHAN DMPRTILRIS EIPSSLPVNH QLHRDLSFLA HTTSRSESSI TSPIVSSSTN
FSYRKRSESS LSGSSPTHTK KLMVWNPPLA EPSFYSPKAA LHPLSTDKAH ASESLSDRLH
NKRPRPIPDN TKCQICADEF STPIELQVHL HVDHVRMMDG AEYKCPRKFC GLNYESLDSL
RAHVTAHYET DRQKLLEEKV LLAEADFPID NSKIEKLNSP KKESMNKFTT PFKAISDHHE
LYAQTQQGAG SSTSNQSPKA AN
