ID   BIG1_YARLI              Reviewed;         332 AA.
AC   Q6CB37;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Protein BIG1;
DE   Flags: Precursor;
GN   Name=BIG1; OrderedLocusNames=YALI0C22187g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for normal beta-1,6-glucan synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BIG1 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82445.1; -; Genomic_DNA.
DR   RefSeq; XP_502125.1; XM_502125.1.
DR   AlphaFoldDB; Q6CB37; -.
DR   STRING; 4952.CAG82445; -.
DR   EnsemblFungi; CAG82445; CAG82445; YALI0_C22187g.
DR   GeneID; 2909688; -.
DR   KEGG; yli:YALI0C22187g; -.
DR   VEuPathDB; FungiDB:YALI0_C22187g; -.
DR   HOGENOM; CLU_837311_0_0_1; -.
DR   InParanoid; Q6CB37; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0006078; P:(1->6)-beta-D-glucan biosynthetic process; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009272; P:fungal-type cell wall biogenesis; IBA:GO_Central.
DR   InterPro; IPR037654; Big1.
DR   PANTHER; PTHR28285; PTHR28285; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..332
FT                   /note="Protein BIG1"
FT                   /id="PRO_0000277853"
FT   TOPO_DOM        15..266
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..332
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   332 AA;  36711 MW;  6F904B2556C86303 CRC64;
     MKLALLSLIG TALATPAVML SHKELTAFEK YTNKQTSNSI SAVELDRVAR KLMHDCSANT
     YVVVNQPGLK AKDFQTESAF PFLKKLLERT STMYTVPYAD GGIELGKLAN SVAKQCGAVK
     IDVNLDNNIT PLEEYMDTTK RVIEINFEPL PNTYVSRLAA LAANDEMLEK IVRATPSPFI
     ALILTSQKGE EGDFETRNPD FKIFPGVARA KTVPGAKDKY KYHMELQNVP VDEKKLTAEA
     LLKVKTPPTH APEVRQTGDG ELVDDKLLLM IVGSVVAILL SLLVFNGLMA AKPDVVKVDK
     TDAKVEKAVK KEVQKKERLV NGRVEQLKRE TR