ID   SMAG1_XENLA             Reviewed;         710 AA.
AC   Q5FWP2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein Smaug homolog 1;
DE            Short=Smaug 1;
DE   AltName: Full=Sterile alpha motif domain-containing protein 4A;
GN   Name=samd4a; Synonyms=smaug1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a translational repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection,
CC       dendrite {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMAUG family. {ECO:0000305}.
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DR   EMBL; BC089262; AAH89262.1; -; mRNA.
DR   RefSeq; NP_001089983.1; NM_001096514.1.
DR   AlphaFoldDB; Q5FWP2; -.
DR   SMR; Q5FWP2; -.
DR   BioGRID; 592835; 1.
DR   IntAct; Q5FWP2; 1.
DR   DNASU; 735054; -.
DR   GeneID; 735054; -.
DR   KEGG; xla:735054; -.
DR   CTD; 735054; -.
DR   Xenbase; XB-GENE-6254504; samd4a.S.
DR   OrthoDB; 670335at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 735054; Expressed in blastula and 19 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0030371; F:translation repressor activity; IEA:InterPro.
DR   GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR   CDD; cd09557; SAM_Smaug; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.25.40.170; -; 2.
DR   InterPro; IPR037093; PHAT_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037634; Smaug_SAM.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Reference proteome; Repressor; Synapse;
KW   Synaptosome; Translation regulation.
FT   CHAIN           1..710
FT                   /note="Protein Smaug homolog 1"
FT                   /id="PRO_0000380126"
FT   DOMAIN          319..379
FT                   /note="SAM"
FT   REGION          276..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  78756 MW;  970FEAE59AE028A0 CRC64;
     MMFRDQVGML SGWFKGWNEC EQTVALLSLL KRVSRTQARF LQICLEHSLV DCTELHILEG
     EANNPAIINQ WQQESKDKVI SQLLTHLPLL KPGNIDAKMA YMKLLPKILA HSIEHNQHIE
     ESRQLLSYAL IHPATSLDDR SALAMWLNHL EDRTSGNFST QSRCRSDSLD YGQMQYYHQR
     QNSDDKQNGW PNSRDSGICI SSSGWQEKNT GCENGHLPLY SSSSVPSTIN AIGTSTILSG
     QTHHSSLKRS VSLTPPMNVP NQPLGHGWMS HEDLRARGSQ GIPSDHAPLS PQSSVASSGS
     GGSEHLEEQS TACNTFQDEG SGMKDVPAWL KSLRLHKYAA LFSHITYDEM MSLNECHLEA
     QNVTKGARHK IVISIQKLKE RHNLLKTLER DVLEGGNLRV PLQELHQIIL TPIKACFPQN
     SNTEEHDQEA DSQPPLLASK NQATESKDSA SGGIQQHHIG NCESESGGVP LPESDLPGQF
     TRVMGKVCTQ LLVSRPDEEN ISSYLQLIDK CLTHDAFTET QKKRLLSWKQ QVQKLFRSFP
     RKSLLDVAGY RQQRKTSVDV LIGSRGFGQS NSLPTAGSVG SGIARRNPRQ FQIPSRNLPS
     TRLSLLGASS LLGATQRASA SNPAMLKQGR QNLWFANPGG SNSMPSRSHS SVQRTRSLPV
     HTSPQTMLMF QQQDFQVPVT EPDINNRLES LCLSMTEHAL GDGVDRTSTI