ID   SMAG1_XENTR             Reviewed;         712 AA.
AC   Q0IHW3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein Smaug homolog 1;
DE            Short=Smaug 1;
DE   AltName: Full=Sterile alpha motif domain-containing protein 4A;
GN   Name=samd4a; Synonyms=smaug1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a translational repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection,
CC       dendrite {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMAUG family. {ECO:0000305}.
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DR   EMBL; BC122938; AAI22939.1; -; mRNA.
DR   RefSeq; NP_001072580.1; NM_001079112.1.
DR   RefSeq; XP_012824084.1; XM_012968630.2.
DR   AlphaFoldDB; Q0IHW3; -.
DR   SMR; Q0IHW3; -.
DR   DNASU; 780035; -.
DR   Ensembl; ENSXETT00000072007; ENSXETP00000073845; ENSXETG00000012217.
DR   GeneID; 780035; -.
DR   KEGG; xtr:780035; -.
DR   CTD; 23034; -.
DR   Xenbase; XB-GENE-978113; samd4a.
DR   InParanoid; Q0IHW3; -.
DR   OrthoDB; 670335at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012217; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR   CDD; cd09557; SAM_Smaug; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.25.40.170; -; 2.
DR   InterPro; IPR037093; PHAT_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037634; Smaug_SAM.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Reference proteome; Repressor; Synapse;
KW   Synaptosome; Translation regulation.
FT   CHAIN           1..712
FT                   /note="Protein Smaug homolog 1"
FT                   /id="PRO_0000380127"
FT   DOMAIN          321..381
FT                   /note="SAM"
FT   REGION          278..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   712 AA;  79124 MW;  8182760DAF05D3D2 CRC64;
     MMFRDQVGML SGWFKGWNEC EQTVALLSLL KRVSRTQARF LQICLEHSLV DCTELHILEG
     EANNPAIINQ WQQESKDKVI SQLLTHLPLL KPGNIDAKVA YMKLLPKILA HSIEHNQHIE
     ESRQLLSYAL IHPATSLDDR SALAMWLNHL EDRTSGNFST QSRCRSDSLD YGQMQYYHQR
     QNSDDKQNGW PNSRDSGICV SSSGWQEKNT GCENGHLPLY SSSSVPSTIN AIGTNTSTIL
     SGQTHHSPLK RSVSLTPPMN VPNQPLGHGW MSHEDLRARG SQGIPSDHAP LSPQSSVASS
     GSGGSEHLEE QSTARNTFQD EGSGMKDVPA WLKSLRLHKY AALFSHMSYE EMMSLNECQL
     EAQNVTKGAR HKIVISIQKL KERHNLLKTL ERDILEGGNL RVPLQELHQM ILTPIKTYSP
     QNSNTEEHNR EADSQPTLLV AENQASESKD SASAGIQQHH ISNCETESGG VPLPEGDLPG
     QFTRVMGKVC TQLLVSRPDE ENISSYLQLI DKCLTHEAFT ETQKKRLLSW KQQVQKLFRS
     FPRKSLLDVA GYRQQRKTSV DVLIGSRAFG QSNSLPTAGS VGSGIARRNP RQFQIPSRNL
     PSTRLSLLGA SSLLGAPQRA SASNPAMLKQ GRQNLWFANP GGSNSMPSRT HSSVQRTRSL
     PVHTSPQTML MFQQPDFQVP VTEPDINNRL ESLCLSMTEH ALGDGVDRTS TI