SMAGP_HUMAN
ID SMAGP_HUMAN Reviewed; 97 AA.
AC Q0VAQ4; A6NIL5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Small cell adhesion glycoprotein;
DE AltName: Full=Small transmembrane and glycosylated protein;
GN Name=SMAGP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP GLYCOSYLATION.
RX PubMed=15021913; DOI=10.1038/sj.onc.1207469;
RA Tarbe N.G., Rio M.-C., Weidle U.H.;
RT "SMAGP, a new small trans-membrane glycoprotein altered in cancer.";
RL Oncogene 23:3395-3403(2004).
RN [5]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=15986429; DOI=10.1002/ijc.21275;
RA Tarbe N.G., Rio M.-C., Hummel S., Weidle U.H., Zoeller M.;
RT "Overexpression of the small transmembrane and glycosylated protein SMAGP
RT supports metastasis formation of a rat pancreatic adenocarcinoma line.";
RL Int. J. Cancer 117:913-922(2005).
CC -!- FUNCTION: May play a role in epithelial cell-cell contacts. May play a
CC role in tumor invasiveness and metastasis formation.
CC {ECO:0000269|PubMed:15986429}.
CC -!- INTERACTION:
CC Q0VAQ4; Q96BI3: APH1A; NbExp=3; IntAct=EBI-10226799, EBI-2606935;
CC Q0VAQ4; Q13520: AQP6; NbExp=3; IntAct=EBI-10226799, EBI-13059134;
CC Q0VAQ4; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10226799, EBI-11343438;
CC Q0VAQ4; P54709: ATP1B3; NbExp=3; IntAct=EBI-10226799, EBI-1054481;
CC Q0VAQ4; A8MZ97: C2orf74; NbExp=3; IntAct=EBI-10226799, EBI-3943880;
CC Q0VAQ4; P19397: CD53; NbExp=3; IntAct=EBI-10226799, EBI-6657396;
CC Q0VAQ4; Q15125: EBP; NbExp=3; IntAct=EBI-10226799, EBI-3915253;
CC Q0VAQ4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10226799, EBI-781551;
CC Q0VAQ4; O15552: FFAR2; NbExp=3; IntAct=EBI-10226799, EBI-2833872;
CC Q0VAQ4; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10226799, EBI-11721746;
CC Q0VAQ4; P26951: IL3RA; NbExp=3; IntAct=EBI-10226799, EBI-1757512;
CC Q0VAQ4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10226799, EBI-10266796;
CC Q0VAQ4; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-10226799, EBI-373355;
CC Q0VAQ4; P41143: OPRD1; NbExp=3; IntAct=EBI-10226799, EBI-2624456;
CC Q0VAQ4; P35372-10: OPRM1; NbExp=3; IntAct=EBI-10226799, EBI-12807478;
CC Q0VAQ4; P57054: PIGP; NbExp=3; IntAct=EBI-10226799, EBI-17630288;
CC Q0VAQ4; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-10226799, EBI-11721828;
CC Q0VAQ4; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-10226799, EBI-12955265;
CC Q0VAQ4; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10226799, EBI-7545592;
CC Q0VAQ4; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-10226799, EBI-18397230;
CC Q0VAQ4; O43765: SGTA; NbExp=3; IntAct=EBI-10226799, EBI-347996;
CC Q0VAQ4; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10226799, EBI-18159983;
CC Q0VAQ4; O60669: SLC16A7; NbExp=3; IntAct=EBI-10226799, EBI-3921243;
CC Q0VAQ4; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-10226799, EBI-17498703;
CC Q0VAQ4; Q96L08: SUSD3; NbExp=3; IntAct=EBI-10226799, EBI-18194029;
CC Q0VAQ4; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-10226799, EBI-12947623;
CC Q0VAQ4; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-10226799, EBI-2821497;
CC Q0VAQ4; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10226799, EBI-8638294;
CC Q0VAQ4; Q6UW68: TMEM205; NbExp=3; IntAct=EBI-10226799, EBI-6269551;
CC Q0VAQ4; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-10226799, EBI-8642211;
CC Q0VAQ4; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-10226799, EBI-3923061;
CC Q0VAQ4; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-10226799, EBI-726044;
CC Q0VAQ4; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10226799, EBI-11742770;
CC Q0VAQ4; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-10226799, EBI-11724433;
CC Q0VAQ4; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10226799, EBI-6447886;
CC Q0VAQ4; O00526: UPK2; NbExp=3; IntAct=EBI-10226799, EBI-10179682;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15021913};
CC Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic
CC vesicle membrane {ECO:0000269|PubMed:15986429}; Single-pass type III
CC membrane protein {ECO:0000255}. Note=Predominantly on lateral parts of
CC the membrane, at cell-cell epithelial junctions (PubMed:15021913).
CC Detected on cytoplasmic membranes in undifferentiated tumors
CC (PubMed:15986429). {ECO:0000269|PubMed:15021913,
CC ECO:0000269|PubMed:15986429}.
CC -!- TISSUE SPECIFICITY: Detected in breast, endometrium, colon and biliary
CC tract. Detected in polarized epithelial structures characterized by
CC cell-cell adhesion (at protein level). {ECO:0000269|PubMed:15021913}.
CC -!- PTM: O-glycosylated. The O-glycan is modified with sialic acid
CC residues. {ECO:0000269|PubMed:15021913}.
CC -!- SIMILARITY: Belongs to the SMAGP family. {ECO:0000305}.
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DR EMBL; AC046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471111; EAW58184.1; -; Genomic_DNA.
DR EMBL; BC008712; AAH08712.2; -; mRNA.
DR EMBL; BC120965; AAI20966.1; -; mRNA.
DR EMBL; BC120966; AAI20967.1; -; mRNA.
DR CCDS; CCDS44889.1; -.
DR RefSeq; NP_001026798.1; NM_001031628.1.
DR RefSeq; NP_001029045.1; NM_001033873.1.
DR AlphaFoldDB; Q0VAQ4; -.
DR SMR; Q0VAQ4; -.
DR BioGRID; 121462; 40.
DR IntAct; Q0VAQ4; 36.
DR STRING; 9606.ENSP00000475068; -.
DR GlyGen; Q0VAQ4; 8 sites.
DR iPTMnet; Q0VAQ4; -.
DR PhosphoSitePlus; Q0VAQ4; -.
DR BioMuta; SMAGP; -.
DR DMDM; 121940462; -.
DR EPD; Q0VAQ4; -.
DR jPOST; Q0VAQ4; -.
DR MassIVE; Q0VAQ4; -.
DR MaxQB; Q0VAQ4; -.
DR PaxDb; Q0VAQ4; -.
DR PeptideAtlas; Q0VAQ4; -.
DR PRIDE; Q0VAQ4; -.
DR ProteomicsDB; 58808; -.
DR TopDownProteomics; Q0VAQ4; -.
DR Antibodypedia; 42988; 109 antibodies from 22 providers.
DR DNASU; 57228; -.
DR Ensembl; ENST00000398453.7; ENSP00000381471.2; ENSG00000170545.17.
DR Ensembl; ENST00000603798.6; ENSP00000475068.1; ENSG00000170545.17.
DR Ensembl; ENST00000603864.5; ENSP00000474892.1; ENSG00000170545.17.
DR GeneID; 57228; -.
DR KEGG; hsa:57228; -.
DR MANE-Select; ENST00000603798.6; ENSP00000475068.1; NM_001031628.2; NP_001026798.1.
DR UCSC; uc001ryd.2; human.
DR CTD; 57228; -.
DR DisGeNET; 57228; -.
DR GeneCards; SMAGP; -.
DR HGNC; HGNC:26918; SMAGP.
DR HPA; ENSG00000170545; Tissue enhanced (esophagus, placenta).
DR neXtProt; NX_Q0VAQ4; -.
DR OpenTargets; ENSG00000170545; -.
DR PharmGKB; PA165513352; -.
DR VEuPathDB; HostDB:ENSG00000170545; -.
DR eggNOG; ENOG502S7EH; Eukaryota.
DR GeneTree; ENSGT00390000010077; -.
DR InParanoid; Q0VAQ4; -.
DR OMA; AVQMEDD; -.
DR OrthoDB; 1493389at2759; -.
DR PhylomeDB; Q0VAQ4; -.
DR TreeFam; TF337016; -.
DR PathwayCommons; Q0VAQ4; -.
DR SignaLink; Q0VAQ4; -.
DR BioGRID-ORCS; 57228; 91 hits in 1078 CRISPR screens.
DR ChiTaRS; SMAGP; human.
DR GenomeRNAi; 57228; -.
DR Pharos; Q0VAQ4; Tbio.
DR PRO; PR:Q0VAQ4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q0VAQ4; protein.
DR Bgee; ENSG00000170545; Expressed in lower esophagus mucosa and 154 other tissues.
DR ExpressionAtlas; Q0VAQ4; baseline and differential.
DR Genevisible; Q0VAQ4; HS.
DR GO; GO:0030054; C:cell junction; IDA:HPA.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR043243; SMAGP.
DR PANTHER; PTHR47394; PTHR47394; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasmic vesicle; Glycoprotein; Membrane;
KW Reference proteome; Sialic acid; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Small cell adhesion glycoprotein"
FT /id="PRO_0000328795"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 97 AA; 10679 MW; 90BC88F950B94904 CRC64;
MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS VVILIFFYLY
KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFI
