SMAGP_MOUSE
ID SMAGP_MOUSE Reviewed; 97 AA.
AC Q99KC7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Small cell adhesion glycoprotein;
DE AltName: Full=Small transmembrane and glycosylated protein;
GN Name=Smagp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Lung, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in epithelial cell-cell contacts. May play a
CC role in tumor invasiveness and metastasis formation (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q0VAQ4};
CC Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic
CC vesicle membrane {ECO:0000250|UniProtKB:Q0VAQ4}; Single-pass type III
CC membrane protein {ECO:0000255}. Note=Predominantly on lateral parts of
CC the membrane, at cell-cell epithelial junctions. Detected on
CC cytoplasmic membranes in undifferentiated tumors.
CC {ECO:0000250|UniProtKB:Q0VAQ4}.
CC -!- PTM: O-glycosylated. The O-glycan is modified with sialic acid residues
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SMAGP family. {ECO:0000305}.
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DR EMBL; BC004728; AAH04728.2; -; mRNA.
DR EMBL; BC132460; AAI32461.1; -; mRNA.
DR EMBL; BC132462; AAI32463.1; -; mRNA.
DR CCDS; CCDS27842.1; -.
DR RefSeq; NP_001029044.1; NM_001033872.2.
DR RefSeq; NP_778157.2; NM_174992.4.
DR AlphaFoldDB; Q99KC7; -.
DR STRING; 10090.ENSMUSP00000066137; -.
DR GlyGen; Q99KC7; 6 sites.
DR iPTMnet; Q99KC7; -.
DR PhosphoSitePlus; Q99KC7; -.
DR MaxQB; Q99KC7; -.
DR PaxDb; Q99KC7; -.
DR PRIDE; Q99KC7; -.
DR ProteomicsDB; 261513; -.
DR Antibodypedia; 42988; 109 antibodies from 22 providers.
DR Ensembl; ENSMUST00000066068; ENSMUSP00000066137; ENSMUSG00000053559.
DR Ensembl; ENSMUST00000172334; ENSMUSP00000126870; ENSMUSG00000053559.
DR GeneID; 207818; -.
DR KEGG; mmu:207818; -.
DR UCSC; uc007xru.2; mouse.
DR CTD; 57228; -.
DR MGI; MGI:2448476; Smagp.
DR VEuPathDB; HostDB:ENSMUSG00000053559; -.
DR eggNOG; ENOG502S7EH; Eukaryota.
DR GeneTree; ENSGT00390000010077; -.
DR HOGENOM; CLU_175196_0_0_1; -.
DR InParanoid; Q99KC7; -.
DR OMA; AVQMEDD; -.
DR OrthoDB; 1609419at2759; -.
DR PhylomeDB; Q99KC7; -.
DR BioGRID-ORCS; 207818; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Smagp; mouse.
DR PRO; PR:Q99KC7; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q99KC7; protein.
DR Bgee; ENSMUSG00000053559; Expressed in secondary oocyte and 212 other tissues.
DR ExpressionAtlas; Q99KC7; baseline and differential.
DR Genevisible; Q99KC7; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR InterPro; IPR043243; SMAGP.
DR PANTHER; PTHR47394; PTHR47394; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasmic vesicle; Glycoprotein; Membrane;
KW Reference proteome; Sialic acid; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Small cell adhesion glycoprotein"
FT /id="PRO_0000328796"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 97 AA; 10696 MW; C68572A7192B9D4F CRC64;
MNNLPATPSP EELMTTPVFQ APETLSPQAE EASTALIAVV ITVVFLTLLS VVTLIFFHLY
KNKGSYVTYE PAEGEPSAIL QMETDSAKGR EKEEYFI
