SMAGP_RAT
ID SMAGP_RAT Reviewed; 97 AA.
AC Q7TPF1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Small cell adhesion glycoprotein;
DE Short=Small transmembrane and glycosylated protein;
GN Name=Smagp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP GLYCOSYLATION.
RC STRAIN=BDX;
RX PubMed=15021913; DOI=10.1038/sj.onc.1207469;
RA Tarbe N.G., Rio M.-C., Weidle U.H.;
RT "SMAGP, a new small trans-membrane glycoprotein altered in cancer.";
RL Oncogene 23:3395-3403(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=15986429; DOI=10.1002/ijc.21275;
RA Tarbe N.G., Rio M.-C., Hummel S., Weidle U.H., Zoeller M.;
RT "Overexpression of the small transmembrane and glycosylated protein SMAGP
RT supports metastasis formation of a rat pancreatic adenocarcinoma line.";
RL Int. J. Cancer 117:913-922(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May play a role in epithelial cell-cell contacts. May play a
CC role in tumor invasiveness and metastasis formation.
CC {ECO:0000269|PubMed:15986429}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15021913};
CC Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic
CC vesicle membrane {ECO:0000269|PubMed:15986429}; Single-pass type III
CC membrane protein {ECO:0000255}. Note=Predominantly on lateral parts of
CC the membrane, at cell-cell epithelial junctions (PubMed:15021913).
CC Detected on cytoplasmic membranes in undifferentiated tumors.
CC {ECO:0000269|PubMed:15021913, ECO:0000269|PubMed:15986429}.
CC -!- TISSUE SPECIFICITY: Detected in brain (at protein level). Highly
CC expressed in kidney and placenta. Detected in skin, breast, heart,
CC lung, liver, prostate, spleen, small intestine, colon and stomach.
CC {ECO:0000269|PubMed:15021913}.
CC -!- PTM: O-glycosylated. The O-glycan is modified with sialic acid
CC residues. {ECO:0000269|PubMed:15021913}.
CC -!- SIMILARITY: Belongs to the SMAGP family. {ECO:0000305}.
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DR EMBL; AJ577837; CAE12295.1; -; mRNA.
DR EMBL; BC101910; AAI01911.1; -; mRNA.
DR RefSeq; NP_877969.1; NM_182817.1.
DR RefSeq; XP_006242385.1; XM_006242323.3.
DR AlphaFoldDB; Q7TPF1; -.
DR STRING; 10116.ENSRNOP00000066061; -.
DR GlyGen; Q7TPF1; 6 sites.
DR PaxDb; Q7TPF1; -.
DR Ensembl; ENSRNOT00000117455; ENSRNOP00000088015; ENSRNOG00000062981.
DR GeneID; 300236; -.
DR KEGG; rno:300236; -.
DR UCSC; RGD:727777; rat.
DR CTD; 57228; -.
DR RGD; 727777; Smagp.
DR eggNOG; ENOG502S7EH; Eukaryota.
DR GeneTree; ENSGT00390000010077; -.
DR HOGENOM; CLU_175196_0_0_1; -.
DR InParanoid; Q7TPF1; -.
DR OMA; AVQMEDD; -.
DR OrthoDB; 1609419at2759; -.
DR PhylomeDB; Q7TPF1; -.
DR TreeFam; TF337016; -.
DR PRO; PR:Q7TPF1; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000048932; Expressed in kidney and 18 other tissues.
DR Genevisible; Q7TPF1; RN.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR043243; SMAGP.
DR PANTHER; PTHR47394; PTHR47394; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasmic vesicle; Glycoprotein; Membrane;
KW Reference proteome; Sialic acid; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Small cell adhesion glycoprotein"
FT /id="PRO_0000328797"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 97 AA; 10712 MW; FFD572A65D6E9D43 CRC64;
MNNLPATPSP EELMTTPVFQ APETMSPQAE EASTALIAVV ITVVFLTLLS VVTLIFFYLY
KNKGSYVTYE PAEGEPSAIL QMETDSAKGK EKEEYFI
