SMAL1_CAEEL
ID SMAL1_CAEEL Reviewed; 690 AA.
AC Q8MNV7; Q95ZY8; Q95ZY9;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog {ECO:0000312|WormBase:C16A3.1c};
DE EC=3.6.4.-;
GN Name=smrc-1 {ECO:0000312|WormBase:C16A3.1c};
GN ORFNames=C16A3.1 {ECO:0000312|WormBase:C16A3.1c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: ATP-dependent annealing helicase that catalyzes the rewinding
CC of the stably unwound DNA. {ECO:0000250|UniProtKB:Q9NZC9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NZC9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=c {ECO:0000312|WormBase:C16A3.1c};
CC IsoId=Q8MNV7-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C16A3.1a};
CC IsoId=Q8MNV7-2; Sequence=VSP_012922;
CC Name=b {ECO:0000312|WormBase:C16A3.1b};
CC IsoId=Q8MNV7-3; Sequence=VSP_012921, VSP_012922;
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SMARCAL1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00800}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284603; CCD63219.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD63220.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD63221.1; -; Genomic_DNA.
DR RefSeq; NP_498400.1; NM_065999.4. [Q8MNV7-2]
DR RefSeq; NP_498401.2; NM_066000.2. [Q8MNV7-3]
DR RefSeq; NP_741192.1; NM_171165.3. [Q8MNV7-1]
DR AlphaFoldDB; Q8MNV7; -.
DR SMR; Q8MNV7; -.
DR BioGRID; 41125; 1.
DR STRING; 6239.C16A3.1c; -.
DR EPD; Q8MNV7; -.
DR PaxDb; Q8MNV7; -.
DR PeptideAtlas; Q8MNV7; -.
DR EnsemblMetazoa; C16A3.1a.1; C16A3.1a.1; WBGene00015806. [Q8MNV7-2]
DR EnsemblMetazoa; C16A3.1b.1; C16A3.1b.1; WBGene00015806. [Q8MNV7-3]
DR EnsemblMetazoa; C16A3.1c.1; C16A3.1c.1; WBGene00015806. [Q8MNV7-1]
DR GeneID; 175907; -.
DR KEGG; cel:CELE_C16A3.1; -.
DR UCSC; C16A3.1a; c. elegans. [Q8MNV7-1]
DR CTD; 175907; -.
DR WormBase; C16A3.1a; CE27688; WBGene00015806; smrc-1. [Q8MNV7-2]
DR WormBase; C16A3.1b; CE30605; WBGene00015806; smrc-1. [Q8MNV7-3]
DR WormBase; C16A3.1c; CE30606; WBGene00015806; smrc-1. [Q8MNV7-1]
DR eggNOG; KOG1000; Eukaryota.
DR GeneTree; ENSGT00940000172463; -.
DR InParanoid; Q8MNV7; -.
DR OMA; RIMICDE; -.
DR OrthoDB; 1082831at2759; -.
DR PhylomeDB; Q8MNV7; -.
DR PRO; PR:Q8MNV7; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015806; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0043596; C:nuclear replication fork; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0036310; F:ATP-dependent DNA/DNA annealing activity; ISS:UniProtKB.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0031297; P:replication fork processing; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR Gene3D; 3.40.50.10810; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030101; HARP(SMARCAL1).
DR InterPro; IPR010003; HARP_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45766:SF3; PTHR45766:SF3; 1.
DR Pfam; PF07443; HARP; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51467; HARP; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Chromatin regulator; Helicase;
KW Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..690
FT /note="SWI/SNF-related matrix-associated actin-dependent
FT regulator of chromatin subfamily A-like protein 1 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000074350"
FT DOMAIN 92..170
FT /note="HARP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00800"
FT DOMAIN 209..367
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 482..639
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 316..319
FT /note="DESH box"
FT BINDING 222..229
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT VAR_SEQ 31
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_012921"
FT VAR_SEQ 62..64
FT /note="Missing (in isoform a and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_012922"
SQ SEQUENCE 690 AA; 77930 MW; 44C6EDF5F1D28D5F CRC64;
MVLTDEQRQA IAKKREEAIR RAAAYREREM QAAANATAST SSAAPPAPPK PVIPVMFSQN
RQNFQPMKPT MNNSTKQSTI NNYIKQVQKP EPTSLIKPTI GVKLKLDIGD RIKIEFYPFH
SAVIDLIKQV PSRNYDPAKR SWTVASSDHI TISNILKNAT AVKVELEPLP QNIIGLTNFK
PKAAPSDLNT VMDPSLIERL FPYQKEGVIF ALERDGRILL ADEMGLGKSV QALTIARYYK
ADWPLLIVCP ASVKGAWKKQ LNTFFPIIHR IFIVDKSSDP LPDVCTSNTV AIMSYEQMVL
KHDILKKEKY RTIIFDESHM LKDGKARRTK VATDLSKVAL HVILLSGTPA LSRPSELFTQ
IRLIDHKLFT NFHEFAIRYC DGKQGRFCFE AKGCTNSEEL AAIMFKRLMI RRLKADVLKD
LPEKRREVVY VSGPTIDARM DDLQKARADY EKVNSMERKH ESLLEFYSLT GIVKAAAVCE
HILENYFYPD APPRKVLIFA HHQIVLDTIQ VEVNKRKLGS IRIDGKTPSH RRTALCDSFQ
TDDNIRVAVL SITAAGVGIT LTAASVVVFA EIHFNPGYLV QAEDRAHRVG QKDSVFVQYL
IAKKTADDVM WNMVQQKLDV LGQVSLSSDT FRTADKMHLR FNDAAQPGIA EYLKKTPDTT
IDEWEDPVEE KEDDDLEIIC DSPAPKRIKN
