ID   SMAP2_CHICK             Reviewed;         428 AA.
AC   Q5F413;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Stromal membrane-associated protein 2;
DE   AltName: Full=Stromal membrane-associated protein 1-like;
GN   Name=SMAP2; Synonyms=SMAP1L; ORFNames=RCJMB04_3n15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: GTPase activating protein. May play a role in clathrin-
CC       dependent retrograde transport from early endosomes to the trans-Golgi
CC       network (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: May interact with clathrin heavy chains. {ECO:0000250}.
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DR   EMBL; AJ851487; CAH65121.1; -; mRNA.
DR   RefSeq; NP_001026073.1; NM_001030902.1.
DR   AlphaFoldDB; Q5F413; -.
DR   SMR; Q5F413; -.
DR   STRING; 9031.ENSGALP00000039979; -.
DR   Ensembl; ENSGALT00000050934; ENSGALP00000045717; ENSGALG00000029244.
DR   GeneID; 419641; -.
DR   KEGG; gga:419641; -.
DR   CTD; 64744; -.
DR   VEuPathDB; HostDB:geneid_419641; -.
DR   eggNOG; KOG0703; Eukaryota.
DR   GeneTree; ENSGT00940000158387; -.
DR   InParanoid; Q5F413; -.
DR   OMA; MMGYGQS; -.
DR   OrthoDB; 1097163at2759; -.
DR   PhylomeDB; Q5F413; -.
DR   PRO; PR:Q5F413; -.
DR   Proteomes; UP000000539; Chromosome 23.
DR   Bgee; ENSGALG00000029244; Expressed in granulocyte and 13 other tissues.
DR   ExpressionAtlas; Q5F413; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.220.150; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..428
FT                   /note="Stromal membrane-associated protein 2"
FT                   /id="PRO_0000235843"
FT   DOMAIN          13..139
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   ZN_FING         28..51
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REGION          161..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  46315 MW;  01903194C57985F3 CRC64;
     MTGKSVRDVE RYQAVLGSLL SEEENKYCAD CQAKGPRWAS WNIGVFICIR CAGIHRNLGV
     HISRVKSVNL DQWTQEQIQC MQEMGNGKAN RLYEAFLPEN FRRPQTDQAV EGFIRDKYEK
     KKYMDRSIDI NTFRKEKDDK WKKSNEPVSE RKLEPIVFEK VKMPQKKEET QQSRKSSPKS
     TEPVIDLLGL DAPVPSTLTN GRPCSLEKDL DLFASVGLNS DSRKVSGSMP TSGSAGSVPE
     NLNLFPEPGG KGEEAGKKQL SKDSILSLYG SQTPQLPAQG AMFMAPAQMA YPAAAYTSFP
     GVPPSSSMMG GMMAPSVGVM AQHGAAGMVT PMAIPAGYVG NVQAAVIGVP NGMMAAQQAG
     YVAGMAAVPQ PVYGVQPAQQ LQWNITQMTQ QMAGMNFYGA NGVMGYGQSM GGGGAQGSNQ
     SLSTQLWK