BIGA_SALTY
ID BIGA_SALTY Reviewed; 1953 AA.
AC P25927; P25928; Q9XCQ3;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Putative surface-exposed virulence protein BigA;
DE Flags: Precursor;
GN Name=bigA; OrderedLocusNames=STM3478;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RA Stojiljkovic I., Valentine P., Heffron F.;
RT "Salmonella typhimurium rhs homolog.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-765.
RC STRAIN=LT2;
RX PubMed=1987123; DOI=10.1128/jb.173.1.325-333.1991;
RA Wu J.Y., Siegel L.M., Kredich N.M.;
RT "High-level expression of Escherichia coli NADPH-sulfite reductase:
RT requirement for a cloned cysG plasmid to overcome limiting siroheme
RT cofactor.";
RL J. Bacteriol. 173:325-333(1991).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA27042.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAA27042.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAA27043.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF133696; AAD39458.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22340.1; -; Genomic_DNA.
DR EMBL; M64606; AAA27042.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M64606; AAA27043.1; ALT_FRAME; Genomic_DNA.
DR PIR; C39200; C39200.
DR PIR; D39200; D39200.
DR RefSeq; NP_462381.1; NC_003197.2.
DR RefSeq; WP_010989077.1; NC_003197.2.
DR AlphaFoldDB; P25927; -.
DR STRING; 99287.STM3478; -.
DR TCDB; 1.B.12.5.5; the autotransporter-1 (at-1) family.
DR PaxDb; P25927; -.
DR PRIDE; P25927; -.
DR EnsemblBacteria; AAL22340; AAL22340; STM3478.
DR GeneID; 1255001; -.
DR KEGG; stm:STM3478; -.
DR PATRIC; fig|99287.12.peg.3676; -.
DR HOGENOM; CLU_000396_0_1_6; -.
DR PhylomeDB; P25927; -.
DR BioCyc; SENT99287:STM3478-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; SSF103515; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Signal; Virulence.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..1953
FT /note="Putative surface-exposed virulence protein BigA"
FT /id="PRO_0000020808"
FT REPEAT 101..103
FT /note="1; truncated"
FT REPEAT 104..113
FT /note="2; truncated"
FT REPEAT 114..122
FT /note="3; truncated"
FT REPEAT 123..133
FT /note="4"
FT REPEAT 134..144
FT /note="5"
FT REPEAT 145..155
FT /note="6"
FT REPEAT 156..166
FT /note="7"
FT REPEAT 167..177
FT /note="8"
FT REPEAT 178..188
FT /note="9"
FT REPEAT 189..199
FT /note="10"
FT REPEAT 200..210
FT /note="11"
FT REPEAT 211..221
FT /note="12"
FT REPEAT 222..232
FT /note="13"
FT REPEAT 233..243
FT /note="14"
FT REPEAT 244..252
FT /note="15; truncated"
FT DOMAIN 1649..1952
FT /note="Autotransporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..252
FT /note="15 X 11 AA tandem repeats"
FT REGION 1496..1517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..250
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 207
FT /note="D -> DRGDDDVTPPDD (in Ref. 1; AAD39458)"
FT /evidence="ECO:0000305"
FT CONFLICT 514
FT /note="A -> R (in Ref. 3; AAA27043)"
FT /evidence="ECO:0000305"
FT CONFLICT 1698
FT /note="D -> N (in Ref. 1; AAD39458)"
FT /evidence="ECO:0000305"
FT CONFLICT 1795..1798
FT /note="QYLE -> ITLQ (in Ref. 1; AAD39458)"
FT /evidence="ECO:0000305"
FT CONFLICT 1836..1837
FT /note="SA -> T (in Ref. 1; AAD39458)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1953 AA; 200151 MW; 611B3F1C954D91AE CRC64;
MNPMQKKKLI SIAIALTLQS YYIPAIAAEN NDDEKECPSN ISSLPKEKRA KLSPTCLATP
ENDNHWGWVA GGVAALVAGV AIGVENNGGG DSNHSYTPPK PDNGGDVTPP DDGGNVTPPD
DGGNVTPPDD GGDDNVTPPD DSGDDDVAPP DDSGDDDVTP PDDSGDDDVT PPDDSGDGDV
TPPDDSGDDD VTPPDDSGDD DVTPPDDSGD DDVTPPDDSG DDDVTPPDDS GDDDVTPPDD
SGDDDDTPPD DSVITFSNGV TIDKGKDTLT FDSFKLDNGS VLEGAVWNYS EQDNQWQLTT
ADGKTLNVTG WDVTDANAAV IEGTQENGLY WKYDSRGYLI IADDNTTVIS GDDQAHNSDR
GMDISGQDRT GVIISGDRTV NTLTGDSSVT DGATGMVISG DGTTNTISGH STVDNATGAL
ISGNGTTTNF AGDIAVSGGG TAIIIDGDNA TIKNTGTSDI SGAGSTGTVI DGNNARVNND
GDMTITDGGT GGHITGDNVV IDNAGSTTVS GADATALYIE GDNALVINEG NQTISGGAVG
TRIDGDDAHT TNTGDIAVDG AGSAAVIING DNGSLTQAGD LLVTDGAMGI ITYGTGNEAK
NTGNATVRDA DSVGFVVAGE KNTFKNKGDI DVSLNGTGAL VSGDMSQVTL DGDINVVSVQ
DSEGVFSSAT GVSVSGDSNA VDITGNVNIS ADYGQDDLAA GAPPLTGVVV GGNGNTVTLN
GALNIDDNDL SATGGQYLDV VGLSVTGDDN DVEIDGGINI THSEDPLDGT SADITGISVS
GNSTVTLNGH STIDTNTVVG GHVVLARVNN GGSLILGDDS VVDVNVSYIP TGYYTYNALL
MADGEGTSIE NKGDITSHGV YSVIRADNGS EVSNSGDILV YATSSNSSED RAAITRASGE
GSAVHNKAGG DITLISDQTP QGSGGIEVYP LKWYTHTFYA MMASDYGDVV NDEGATIHLQ
GAGVYGVTAS RGKALNEGNI YLDGLVPTLD DENNITSTSY WQPSSLYLTS SGMVAGSTDA
DGDATAINTG NITVNNAGFG MMALNGGTAI NQGVITLTAD DGVTGQADEL VGMAALNGGV
VINDTSGVIN IDADYGQAFL SDSSSYIINN GSINLNGSPM DDTDSHMGGT PTDKIWIQSL
PGSGDSDTRT SDTGFFTAGT LANYGTETLN GDVDVNGGWL YNEAGASLTV NGTVTINGGA
NALANYGTLD ADAISTWHSL FNEADGSITT DLLTLNGDVT FYNNGDFTGS IAGTSYQQEI
VNTGDMTVAE DGKSLVSGSF YFYNEEDATL TNSGSAVEGG ENTIINLTRA NDSLTQVNSG
TITATNGYSA ITTVNGSNDP KWIWNTATGV INGINPDAPL INLGRGYNFG NQGTINVQGD
NAVAISGGTS SYVINLVNSG TINVGTEQGK EDGTNGTGLI GIKGNGNATT INNTADGVIN
VYADDSYAFG GKTKAIINNG EINLLCDSGC DIYAPGTTGT QNDHNGTADI VIPDATTAPT
EGSIPTPPAD PNAPQQLSNY IVGTNADGSS GTLKANNLVI GDNVKVDTGF TSGTADTTVV
VDNAFTGSNI QGADNITSTS VVWNAQGSQD ADGNVDVTMT KNAYADVATD SSVSDVAQAL
DAGYTNNELY TSLNVGTTAE LNSALKQVSG AQATTVFREA RVLSNRFTML ADAAPQIKDG
LAFNVVAKGD PRAELGNDTQ YDMLALRQTL DLTASQNLTL EYGIARLDGD GSKTAGDNGL
TGGYSQFFGL KHSMAFDEGL AWNNSLRYDV HNLDSSRSVA YGDVNKIADS DMRQQYLEFR
SEGAKTFTMM GDALKVTPYA GVKFRHTMED GYKERSAGDF NLSMNSGNET AVDSIVGLKL
DYAGKDGWSA TATLEGGPNL SYSKSQRTAS LQGAAGQSFG VDDGQKGGGV NGLATIGVKY
SSNDTALHLD AYQWKEDGIS DKGFMLNVKK TFR
