SMC2_PLAF7
ID SMC2_PLAF7 Reviewed; 1218 AA.
AC Q8IED2;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Structural maintenance of chromosomes protein 2 {ECO:0000250|UniProtKB:O95347};
GN ORFNames=MAL13P1.96;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 862-918, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- FUNCTION: May play a role in the conversion of interphase chromatin
CC into condensed chromosomes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95347}.
CC -!- DOMAIN: The SMC hinge domain, which separates the large intramolecular
CC coiled coil regions, allows the heterodimerization with smc4 forming a
CC V-shaped heterodimer. {ECO:0000250|UniProtKB:Q9C5Y4}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily. {ECO:0000255}.
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DR EMBL; AL844509; CAD52328.1; -; Genomic_DNA.
DR RefSeq; XP_001349920.1; XM_001349884.1.
DR AlphaFoldDB; Q8IED2; -.
DR SMR; Q8IED2; -.
DR BioGRID; 1209245; 1.
DR IntAct; Q8IED2; 1.
DR STRING; 5833.MAL13P1.96; -.
DR PRIDE; Q8IED2; -.
DR EnsemblProtists; CAD52328; CAD52328; PF3D7_1318400.
DR GeneID; 813987; -.
DR KEGG; pfa:PF3D7_1318400; -.
DR VEuPathDB; PlasmoDB:PF3D7_1318400; -.
DR HOGENOM; CLU_001042_9_0_1; -.
DR InParanoid; Q8IED2; -.
DR OMA; HNKIAME; -.
DR PhylomeDB; Q8IED2; -.
DR Reactome; R-PFA-2299718; Condensation of Prophase Chromosomes.
DR Reactome; R-PFA-2514853; Condensation of Prometaphase Chromosomes.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000793; C:condensed chromosome; IBA:GO_Central.
DR GO; GO:0000796; C:condensin complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007076; P:mitotic chromosome condensation; ISS:UniProtKB.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; ISS:GeneDB.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF75553; SSF75553; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell cycle; Cell division; Coiled coil; DNA condensation;
KW Merozoite; Mitosis; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..1218
FT /note="Structural maintenance of chromosomes protein 2"
FT /id="PRO_0000388758"
FT DOMAIN 525..654
FT /note="SMC hinge"
FT COILED 209..517
FT /evidence="ECO:0000255"
FT COILED 693..949
FT /evidence="ECO:0000255"
FT COILED 978..1045
FT /evidence="ECO:0000255"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1218 AA; 143059 MW; E1DBD7838BBC7E5B CRC64;
MYIEEIILDG FKSYPTKTVI GPFHPQFNAI TGLNGSGKSN VLDAICFVMG INNLNLIRVN
RLDELIYKQG QAGITKGSVT IKFNNEEKPS PLQEPYRDMK NITITRQIVL GGRNRYLLNS
HNAKPKDISD FFQSLKLNIN NPHFLIMQGK ITKVINMKPI ELLGLIEESS GTKLYEVKRT
NAIKLMVKKD QKLGEINKVL FEEIEPTLVK LKKEKEEYNK FVSNNEEIEK YEKVEIAYKY
YVAKKMMTKC EEKIEDAKSE EKILEKGIKE IDKDIEKYKI EKEKIVKETN TASEPMKILI
SQKEELEKKI SQLKSEAKME NKEKAKEKRR REDIKKEINN LQNKLDDYQK NNEKNNKNLK
SYEDLKKKIE ILKEELNEKQ LTMNCLLSAG TNNNEYTGSF REQLKNYKTN LSKAETQINN
FLQNNKHLEK EIMTLKEQRK KYEKEYNEIS KEKDIEEKKK KLCEQELDKL NKEYNNFMEL
DTLKTDKNIL YNDMEKLQQE LQVLKNIINS VKIDYKIPSN MKSTDVLGQI YKLIKIKKEY
INTALAVHLI LGGKLTYLLV QNKEHSKRLF EYNNFSSGSK RVTLLPLEDC VISREVHEKH
IEECRRNVGL NIKDKNDVIY FLDIMEYDKN LERIIQYLFN GTLICSNVDL CKKITYNPNK
KLSYTTITLE GDKFDTSGSM SGGSNKNINL FLLNYEKYKH KKEQYHDNEN KLKEVSEKLK
SLEKAEEKKK IISKELQIYE NNLNNIENRM ETSKYGSVNK KIEEHKNEID KGRNELSELY
KEQKKLTEVI RKLEKDISEY EANKDKKEED LKETIKKLKN KIKQLETEEH KKKEEIDDVL
LQIENYKKQK EKETNDLSST DEIINEIEKK IEDIEKNINI TKENLKELEN KITELQSSFS
SYENEMKHVV KKIEDLEKKK SENILDLKKL ENTLLDLQKD LKTSSDTVKY LYKTHVWIES
YEPLFNKKYT PYDFENFRHD VIQKKIQALQ NEQNKLSINI NRKAVQMYEQ VQVDYKDLVT
KKSQVEEDKK KIQEVIADLD VKKSESLLAM YQQINEYFQA IFSTLLNNAQ AKLSIVDGDL
ANGIEMKIAF NNNWKESLTE LSGGQRSLLA LSLILALLKV RTVPMYILDE IDAALDLNHT
QNIGDMIRTQ FPHSQFIIVS LKEGMFSHAD VLFKMRFIDG ISTVNRHALD IRQNTNKKEV
QEVKRRRVTI HDKEPDHD
