SMC6_DICDI
ID SMC6_DICDI Reviewed; 1185 AA.
AC Q54I56;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Structural maintenance of chromosomes protein 6;
DE Short=SMC protein 6;
DE Short=SMC-6;
GN Name=smc6; ORFNames=DDB_G0288993;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Core component of the smc5-smc6 complex, a complex involved
CC in DNA double-strand breaks by homologous recombination. The complex
CC may promote sister chromatid homologous recombination by recruiting the
CC smc1-smc3 cohesin complex to double-strand breaks (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterodimer with smc5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC Note=Associates with chromatin. {ECO:0000250}.
CC -!- DOMAIN: The flexible hinge domain, which separates the large
CC intramolecular coiled coil regions, allows the heterotypic interaction
CC with the corresponding domain of smc5, forming a V-shaped heterodimer.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000129; EAL62951.1; -; Genomic_DNA.
DR RefSeq; XP_636454.1; XM_631362.1.
DR AlphaFoldDB; Q54I56; -.
DR SMR; Q54I56; -.
DR STRING; 44689.DDB0231143; -.
DR PaxDb; Q54I56; -.
DR PRIDE; Q54I56; -.
DR EnsemblProtists; EAL62951; EAL62951; DDB_G0288993.
DR GeneID; 8626906; -.
DR KEGG; ddi:DDB_G0288993; -.
DR dictyBase; DDB_G0288993; smc6.
DR eggNOG; KOG0250; Eukaryota.
DR HOGENOM; CLU_009063_0_0_1; -.
DR InParanoid; Q54I56; -.
DR OMA; MCHDHFY; -.
DR PhylomeDB; Q54I56; -.
DR Reactome; R-DDI-3108214; SUMOylation of DNA damage response and repair proteins.
DR PRO; PR:Q54I56; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0030915; C:Smc5-Smc6 complex; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; ISS:dictyBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027132; SMC6.
DR PANTHER; PTHR19306:SF6; PTHR19306:SF6; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; Chromosome; Coiled coil; DNA damage; DNA recombination;
KW DNA repair; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..1185
FT /note="Structural maintenance of chromosomes protein 6"
FT /id="PRO_0000327930"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..807
FT /note="Flexible hinge"
FT COILED 337..570
FT /evidence="ECO:0000255"
FT COILED 808..1024
FT /evidence="ECO:0000255"
FT COMPBIAS 14..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 176..183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1185 AA; 136329 MW; BE024B4D34E8CDED CRC64;
MSKRKLGHDG NSHELDEEEE EEEEDDDDEL IHSTQDQDRP HKQQRVENGK QMTPTKQHQQ
QQQQQPISNG RLKKLKAQSS DEESGSSEDD DEDVEDVDSS GSDSGSSDDD DDDDDDDDDD
DGNSEDEREA VRREQQLKSG VTEPEAGIIE SITLENFMCH RHFKLDFCSN VNFIAGENGS
GKSAVLIALI VCLGAKAGFT NRGSKLSDLV KAETNTAVIT VKLRNQGQEA FKPEKYGKSV
IIERRISRTG SSGYKVKDYN GKTVSDKFND VSLILEQFNI QIDNPMSILT QDTSRQFLNS
AGPQDKYKSF LMATQLDKMT KDYTTIREHI DKIKDMLSQK VVVIQELEKK VREYNKEYKD
LQQMVGLERK ISEFKNQLAW SFVVESEREA KRKEKQVAEA EERSFDNDIR KVDETIETYN
KSIEDIKKDI KEFTDQIKIQ EQKKETNNRE ILTIEREEAK IQTQIEANNK KRQQRKQRRH
LQLQSINEIK ERNAQLANNQ SKLDEIKKKG QQKLQLEARK EELIKEKEDL MRDRENLKRD
HQNQRTITQQ MNREYEGLRV QLNNLRSTQK GENQAYGKGM TDFLHKIEAS RRNFSKLPIG
PIGLSLKIKN ESWAFAIESA ISKATLRNFL VFSIPDGITL QKLGHQFGIK VDYTKIPETT
EVYKTVEHDE LDPSLATVLR VLDSPSHFII NFLIDTKKVE QIGLGNDRKE IDSVLYTDRC
PRGLSQFFDP QGNNYSKTKS GNPFYQAAKN SGEATMLRVN SDAAIQRTQR DMESKLPALN
QQKKIEQELS SDVQAIEHKI SQNDQDQNQC SRKILQITNE IKSIEDTLVQ QTDDYSELEI
GLASLDEEIK SMDEEINIQK AQRTEVAAQK GPFAENNRAL DDQIDVLSNQ LGNIENNLRK
FNEGLRKLNN NKQALLQQQG RSAQERDQFK AEYQRILEIV KEKTDKATQI CERIEIPTNE
TNTTLTNKII QYTKQLEKES RGKRSRTEAL KLFQDANNSL KEISEQRDNI EELATILERN
LNERYKKWQR FRLSISRRSD QYFNIFLSKK GYTGSLTFDH QNGKLDINVE LQKALPSNQN
GTAKGDTKGL SGGERSFSTV SLLLAFWENM ECPFRAMDEF DVFMDEVNRS ISINLLMSKA
EENRSKQYIF VTPLALNHIK TSEYVKVFRV RAPVRTGGDV TVETD
