SMCO1_HUMAN
ID SMCO1_HUMAN Reviewed; 214 AA.
AC Q147U7; B3KW20;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 1;
DE AltName: Full=Single-pass membrane protein with coiled-coil domains 1;
GN Name=SMCO1; Synonyms=C3orf43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q147U7; Q8TC99: FNDC8; NbExp=3; IntAct=EBI-11735944, EBI-12903902;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK123917; BAG53982.1; -; mRNA.
DR EMBL; AC092933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118556; AAI18557.2; -; mRNA.
DR EMBL; BC118636; AAI18637.2; -; mRNA.
DR CCDS; CCDS43192.1; -.
DR RefSeq; NP_001071125.1; NM_001077657.2.
DR RefSeq; NP_001307402.1; NM_001320473.1.
DR AlphaFoldDB; Q147U7; -.
DR SMR; Q147U7; -.
DR BioGRID; 129121; 7.
DR IntAct; Q147U7; 7.
DR MINT; Q147U7; -.
DR STRING; 9606.ENSP00000380671; -.
DR iPTMnet; Q147U7; -.
DR PhosphoSitePlus; Q147U7; -.
DR BioMuta; SMCO1; -.
DR DMDM; 158937233; -.
DR PaxDb; Q147U7; -.
DR PeptideAtlas; Q147U7; -.
DR PRIDE; Q147U7; -.
DR ProteomicsDB; 60183; -.
DR Antibodypedia; 68999; 74 antibodies from 13 providers.
DR DNASU; 255798; -.
DR Ensembl; ENST00000397537.3; ENSP00000380671.2; ENSG00000214097.5.
DR GeneID; 255798; -.
DR KEGG; hsa:255798; -.
DR MANE-Select; ENST00000397537.3; ENSP00000380671.2; NM_001077657.3; NP_001071125.1.
DR UCSC; uc003fws.4; human.
DR CTD; 255798; -.
DR DisGeNET; 255798; -.
DR GeneCards; SMCO1; -.
DR HGNC; HGNC:27407; SMCO1.
DR HPA; ENSG00000214097; Group enriched (heart muscle, skeletal muscle, tongue).
DR neXtProt; NX_Q147U7; -.
DR PharmGKB; PA142672378; -.
DR VEuPathDB; HostDB:ENSG00000214097; -.
DR eggNOG; ENOG502S2Q0; Eukaryota.
DR GeneTree; ENSGT00390000010564; -.
DR HOGENOM; CLU_112082_0_0_1; -.
DR InParanoid; Q147U7; -.
DR OMA; QMYIRDV; -.
DR OrthoDB; 1298284at2759; -.
DR PhylomeDB; Q147U7; -.
DR TreeFam; TF337928; -.
DR PathwayCommons; Q147U7; -.
DR SignaLink; Q147U7; -.
DR BioGRID-ORCS; 255798; 9 hits in 1033 CRISPR screens.
DR ChiTaRS; SMCO1; human.
DR GenomeRNAi; 255798; -.
DR Pharos; Q147U7; Tdark.
DR PRO; PR:Q147U7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q147U7; protein.
DR Bgee; ENSG00000214097; Expressed in hindlimb stylopod muscle and 66 other tissues.
DR ExpressionAtlas; Q147U7; baseline and differential.
DR Genevisible; Q147U7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027875; DUF4547.
DR PANTHER; PTHR35979; PTHR35979; 1.
DR Pfam; PF15080; DUF4547; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..214
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 1"
FT /id="PRO_0000269483"
FT TRANSMEM 65..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 6..42
FT /evidence="ECO:0000255"
FT VARIANT 20
FT /note="H -> Y (in dbSNP:rs9869292)"
FT /id="VAR_050721"
FT VARIANT 64
FT /note="R -> W (in dbSNP:rs11926701)"
FT /id="VAR_050722"
SQ SEQUENCE 214 AA; 24598 MW; 83885306116083AA CRC64;
MNNETTTLIS LKEAMKRVDH KLQALETQFK ELDFTKDNLM QKFEHHSKAL ASQAAQDEMW
TAVRALQLTS MELNILYSYV IEVLICLHTR VLEKLPDLVR GLPTLASVLR RKVKNKRVRV
VWESILEECG LQEGDITALC TFFIARGNKA EHYTAKVRQM YIRDVTFLIT NMVKNQALQD
SLLRAVQVIE KGKAVRTPEK QKSSLEELIP SVKN
