SMCO1_MOUSE
ID SMCO1_MOUSE Reviewed; 214 AA.
AC Q8CEZ1; A3KMI2; E9PUG1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 1;
DE AltName: Full=Single-pass membrane protein with coiled-coil domains 1;
GN Name=Smco1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CEZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CEZ1-2; Sequence=VSP_046481;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI31955.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK009281; BAC25250.1; -; mRNA.
DR EMBL; AC126265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC125555; AAI25556.1; -; mRNA.
DR EMBL; BC131954; AAI31955.1; ALT_INIT; mRNA.
DR CCDS; CCDS28119.2; -. [Q8CEZ1-1]
DR RefSeq; NP_899106.2; NM_183283.2. [Q8CEZ1-1]
DR AlphaFoldDB; Q8CEZ1; -.
DR SMR; Q8CEZ1; -.
DR BioGRID; 213543; 1.
DR STRING; 10090.ENSMUSP00000090873; -.
DR iPTMnet; Q8CEZ1; -.
DR PhosphoSitePlus; Q8CEZ1; -.
DR PaxDb; Q8CEZ1; -.
DR PRIDE; Q8CEZ1; -.
DR ProteomicsDB; 261432; -. [Q8CEZ1-1]
DR ProteomicsDB; 261433; -. [Q8CEZ1-2]
DR Antibodypedia; 68999; 74 antibodies from 13 providers.
DR Ensembl; ENSMUST00000093183; ENSMUSP00000090873; ENSMUSG00000046345. [Q8CEZ1-1]
DR GeneID; 69576; -.
DR KEGG; mmu:69576; -.
DR UCSC; uc007yyn.2; mouse. [Q8CEZ1-1]
DR CTD; 255798; -.
DR MGI; MGI:1916826; Smco1.
DR VEuPathDB; HostDB:ENSMUSG00000046345; -.
DR eggNOG; ENOG502S2Q0; Eukaryota.
DR GeneTree; ENSGT00390000010564; -.
DR HOGENOM; CLU_112082_0_0_1; -.
DR InParanoid; Q8CEZ1; -.
DR OMA; QMYIRDV; -.
DR OrthoDB; 1298284at2759; -.
DR PhylomeDB; Q8CEZ1; -.
DR TreeFam; TF337928; -.
DR BioGRID-ORCS; 69576; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8CEZ1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8CEZ1; protein.
DR Bgee; ENSMUSG00000046345; Expressed in digastric muscle group and 23 other tissues.
DR Genevisible; Q8CEZ1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027875; DUF4547.
DR PANTHER; PTHR35979; PTHR35979; 1.
DR Pfam; PF15080; DUF4547; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..214
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 1"
FT /id="PRO_0000269484"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 193..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..40
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_046481"
SQ SEQUENCE 214 AA; 24517 MW; A594A708B5928731 CRC64;
MTHETTTLIS LKEAMKRVDN KLRALDTQFK ELDVTKDNLT LRFEHHSKTL ASQAAQDEIW
TAALALGFTS MELNIVYSYV IEVLICLHTR MLQKLPDLVR SLPTLASVLR RKAKNKHVRL
VWESVLQEYG LQERDVSALC TFFIVHGNKG EHYAANVRRM YIKDVSFMIT NMVKNQALQD
GLLRAVQIIE KGKQAQDPEN SRAPLKELMP PVKD
