SMCO2_MOUSE
ID SMCO2_MOUSE Reviewed; 347 AA.
AC Q9DA21;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 2;
GN Name=Smco2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK006257; BAB24486.1; -; mRNA.
DR CCDS; CCDS51955.1; -.
DR RefSeq; NP_081335.1; NM_027059.1.
DR AlphaFoldDB; Q9DA21; -.
DR SMR; Q9DA21; -.
DR STRING; 10090.ENSMUSP00000107261; -.
DR iPTMnet; Q9DA21; -.
DR PhosphoSitePlus; Q9DA21; -.
DR PaxDb; Q9DA21; -.
DR PRIDE; Q9DA21; -.
DR ProteomicsDB; 261526; -.
DR Antibodypedia; 2577; 16 antibodies from 9 providers.
DR Ensembl; ENSMUST00000032433; ENSMUSP00000032433; ENSMUSG00000030292.
DR GeneID; 69371; -.
DR KEGG; mmu:69371; -.
DR UCSC; uc009esl.1; mouse.
DR CTD; 341346; -.
DR MGI; MGI:1916621; Smco2.
DR VEuPathDB; HostDB:ENSMUSG00000030292; -.
DR eggNOG; ENOG502RNQM; Eukaryota.
DR GeneTree; ENSGT00940000153380; -.
DR InParanoid; Q9DA21; -.
DR OMA; FQLNHWN; -.
DR OrthoDB; 1093587at2759; -.
DR PhylomeDB; Q9DA21; -.
DR BioGRID-ORCS; 69371; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Smco2; mouse.
DR PRO; PR:Q9DA21; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9DA21; protein.
DR Bgee; ENSMUSG00000030292; Expressed in spermatocyte and 24 other tissues.
DR Genevisible; Q9DA21; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026617; SMCO2/5.
DR PANTHER; PTHR22422; PTHR22422; 1.
DR Pfam; PF14992; TMCO5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..347
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 2"
FT /id="PRO_0000340701"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 139..238
FT /evidence="ECO:0000255"
FT COMPBIAS 32..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 178
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 347 AA; 39357 MW; 34074E619BE47B15 CRC64;
MMSLQLGTAG KERQLAEKSR DLQNVSMTEG SEEVSEMDHI SDRPDEKDKP SENLQTDSLY
KMDTEKWDGL EQESEHSQDP PSKPDEQEVT LVCEGPQVSQ LSPSTDESTP IPESLTHKLN
YWHAKMGLQM KELGADHGDW LERINNIIQN INNTESTVKS LLTEVISLEN QSKNLEDSDQ
EADIEEKITE IRRQLKEVNI KLTQVDACEE ARELKEKLVE QIESFHKEMN VLNSKLEMYY
TQGSDADSHN SEDVDTEQEE PLVPEASPSL SASPTPPCSA VWKNALKLFV IVYVVTITGL
SCYILFVDAT FLFERVLPSV LGHRTMWDLR EMMAPFLNLE AEDLLPS
