SMCO3_HUMAN
ID SMCO3_HUMAN Reviewed; 225 AA.
AC A2RU48; Q8NAI5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 3;
GN Name=SMCO3; Synonyms=C12orf69;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A2RU48; P45984: MAPK9; NbExp=6; IntAct=EBI-10173195, EBI-713568;
CC A2RU48; P60900: PSMA6; NbExp=3; IntAct=EBI-10173195, EBI-357793;
CC A2RU48; Q9HCM9: TRIM39; NbExp=3; IntAct=EBI-10173195, EBI-739510;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03930.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK092637; BAC03930.1; ALT_FRAME; mRNA.
DR EMBL; AC007655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132752; AAI32753.1; -; mRNA.
DR EMBL; BC132754; AAI32755.1; -; mRNA.
DR EMBL; CH471094; EAW96331.1; -; Genomic_DNA.
DR CCDS; CCDS41759.1; -.
DR RefSeq; NP_001013720.2; NM_001013698.2.
DR RefSeq; XP_016874801.1; XM_017019312.1.
DR AlphaFoldDB; A2RU48; -.
DR SMR; A2RU48; -.
DR BioGRID; 136283; 6.
DR IntAct; A2RU48; 7.
DR STRING; 9606.ENSP00000381895; -.
DR iPTMnet; A2RU48; -.
DR PhosphoSitePlus; A2RU48; -.
DR BioMuta; SMCO3; -.
DR EPD; A2RU48; -.
DR MassIVE; A2RU48; -.
DR PaxDb; A2RU48; -.
DR PeptideAtlas; A2RU48; -.
DR PRIDE; A2RU48; -.
DR Antibodypedia; 65695; 49 antibodies from 15 providers.
DR DNASU; 440087; -.
DR Ensembl; ENST00000316048.2; ENSP00000381895.1; ENSG00000179256.2.
DR GeneID; 440087; -.
DR KEGG; hsa:440087; -.
DR MANE-Select; ENST00000316048.2; ENSP00000381895.1; NM_001013698.2; NP_001013720.2.
DR UCSC; uc001rck.1; human.
DR CTD; 440087; -.
DR DisGeNET; 440087; -.
DR GeneCards; SMCO3; -.
DR HGNC; HGNC:34401; SMCO3.
DR HPA; ENSG00000179256; Tissue enhanced (cervix, kidney).
DR neXtProt; NX_A2RU48; -.
DR OpenTargets; ENSG00000179256; -.
DR PharmGKB; PA162378005; -.
DR VEuPathDB; HostDB:ENSG00000179256; -.
DR eggNOG; ENOG502RYUI; Eukaryota.
DR GeneTree; ENSGT00390000013440; -.
DR HOGENOM; CLU_1229530_0_0_1; -.
DR InParanoid; A2RU48; -.
DR OMA; KYQRAIH; -.
DR PhylomeDB; A2RU48; -.
DR TreeFam; TF335698; -.
DR PathwayCommons; A2RU48; -.
DR SignaLink; A2RU48; -.
DR BioGRID-ORCS; 440087; 8 hits in 1058 CRISPR screens.
DR GenomeRNAi; 440087; -.
DR Pharos; A2RU48; Tdark.
DR PRO; PR:A2RU48; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A2RU48; protein.
DR Bgee; ENSG00000179256; Expressed in tibial nerve and 83 other tissues.
DR Genevisible; A2RU48; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027895; DUF4533.
DR InterPro; IPR040004; SMCO3.
DR PANTHER; PTHR35972; PTHR35972; 1.
DR Pfam; PF15047; DUF4533; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..225
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 3"
FT /id="PRO_0000336988"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 62..92
FT /evidence="ECO:0000255"
FT COILED 183..207
FT /evidence="ECO:0000255"
FT VARIANT 49
FT /note="C -> R (in dbSNP:rs11609202)"
FT /id="VAR_043558"
FT VARIANT 75
FT /note="K -> R (in dbSNP:rs2241221)"
FT /id="VAR_043559"
SQ SEQUENCE 225 AA; 24877 MW; 0B80F5E0FF66CD20 CRC64;
MAQSDFLYPE NPKRREEVNR LHQQLLDCLS DSFDVTNKLT EVLNMHLGCR LASIEMKRDG
TIKENCDLII QAIMKIQKEL QKVDEALKDK LEPTLYRKLQ DIKEKETDKI AIVQKVISVI
LGEATSAASA VAVKLVGSNV TTGIINKLVT VLAQIGASLL GSIGVAVLGL GIDMIVRAIL
GAVEKTQLQA AIKSYEKHLV EFKSASEKYN HAITEVINTV KHQMK
