SMCO3_MOUSE
ID SMCO3_MOUSE Reviewed; 225 AA.
AC Q8BQM7; Q8BNZ4; Q8BR60;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 3;
GN Name=Smco3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Corpus striatum, and Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37368.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK078719; BAC37368.1; ALT_FRAME; mRNA.
DR EMBL; AK045581; BAC32422.1; -; mRNA.
DR EMBL; AK047766; BAC33151.1; -; mRNA.
DR CCDS; CCDS20656.1; -.
DR RefSeq; NP_001034647.2; NM_001039558.2.
DR AlphaFoldDB; Q8BQM7; -.
DR STRING; 10090.ENSMUSP00000066235; -.
DR PhosphoSitePlus; Q8BQM7; -.
DR MaxQB; Q8BQM7; -.
DR PaxDb; Q8BQM7; -.
DR PRIDE; Q8BQM7; -.
DR ProteomicsDB; 257266; -.
DR Antibodypedia; 65695; 49 antibodies from 15 providers.
DR Ensembl; ENSMUST00000068293; ENSMUSP00000066235; ENSMUSG00000043298.
DR Ensembl; ENSMUST00000111894; ENSMUSP00000107525; ENSMUSG00000043298.
DR Ensembl; ENSMUST00000203468; ENSMUSP00000144838; ENSMUSG00000043298.
DR GeneID; 654818; -.
DR KEGG; mmu:654818; -.
DR UCSC; uc009emj.1; mouse.
DR CTD; 440087; -.
DR MGI; MGI:2443451; Smco3.
DR VEuPathDB; HostDB:ENSMUSG00000043298; -.
DR eggNOG; ENOG502RYUI; Eukaryota.
DR GeneTree; ENSGT00390000013440; -.
DR HOGENOM; CLU_1229530_0_0_1; -.
DR InParanoid; Q8BQM7; -.
DR OMA; KYQRAIH; -.
DR TreeFam; TF335698; -.
DR BioGRID-ORCS; 654818; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8BQM7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BQM7; protein.
DR Bgee; ENSMUSG00000043298; Expressed in sciatic nerve and 64 other tissues.
DR Genevisible; Q8BQM7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027895; DUF4533.
DR InterPro; IPR040004; SMCO3.
DR PANTHER; PTHR35972; PTHR35972; 1.
DR Pfam; PF15047; DUF4533; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..225
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 3"
FT /id="PRO_0000336989"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 69..92
FT /evidence="ECO:0000255"
FT COILED 182..209
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="F -> L (in Ref. 1; BAC32422)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 24787 MW; D1FCB1F0F162332E CRC64;
MAQSDFLYPQ NPRRRQEVNR LHQQLLDCLS DSFQVTNKLT GVLNTHLGCR LAFIEMKSDG
TIKENCDIII QAMTKIQKEL QKIDEALKDQ LEPTLYRKLQ DIKERETEKI AIVQKVISVI
LGEATSAASA VAVKLVGSSV TTGIISKLVS VLAHIGTSLL GSIGVAVLSL GIDMIIQAIL
GAVERTQLQA AIKSYEKHLE EFKAASAKYH HAITEVATAV KRQLR
