SMCO4_HUMAN
ID SMCO4_HUMAN Reviewed; 59 AA.
AC Q9NRQ5;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 4;
DE AltName: Full=Protein FN5;
GN Name=SMCO4; Synonyms=C11orf75, FN5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10863097; DOI=10.1016/s0378-1119(00)00188-8;
RA Kehrer-Sawatzki H., Moschgath E., Maier C., Legius E., Elgar G., Krone W.;
RT "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1
RT (Neurofibromatosis type 1) gene in the 5' direction and mapping of the
RT human counterparts.";
RL Gene 251:63-71(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NRQ5; Q13520: AQP6; NbExp=3; IntAct=EBI-8640191, EBI-13059134;
CC Q9NRQ5; O60238: BNIP3L; NbExp=7; IntAct=EBI-8640191, EBI-849893;
CC Q9NRQ5; P11912: CD79A; NbExp=3; IntAct=EBI-8640191, EBI-7797864;
CC Q9NRQ5; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-8640191, EBI-2873246;
CC Q9NRQ5; Q9HBJ8: CLTRN; NbExp=3; IntAct=EBI-8640191, EBI-3924906;
CC Q9NRQ5; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-8640191, EBI-18013275;
CC Q9NRQ5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8640191, EBI-6942903;
CC Q9NRQ5; P25025: CXCR2; NbExp=3; IntAct=EBI-8640191, EBI-2835281;
CC Q9NRQ5; Q15125: EBP; NbExp=3; IntAct=EBI-8640191, EBI-3915253;
CC Q9NRQ5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-8640191, EBI-781551;
CC Q9NRQ5; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-8640191, EBI-18636064;
CC Q9NRQ5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8640191, EBI-18304435;
CC Q9NRQ5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-8640191, EBI-18938272;
CC Q9NRQ5; O15552: FFAR2; NbExp=3; IntAct=EBI-8640191, EBI-2833872;
CC Q9NRQ5; P48165: GJA8; NbExp=3; IntAct=EBI-8640191, EBI-17458373;
CC Q9NRQ5; Q9NS71: GKN1; NbExp=3; IntAct=EBI-8640191, EBI-3933251;
CC Q9NRQ5; Q99795: GPA33; NbExp=3; IntAct=EBI-8640191, EBI-4289554;
CC Q9NRQ5; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-8640191, EBI-13345167;
CC Q9NRQ5; O15529: GPR42; NbExp=3; IntAct=EBI-8640191, EBI-18076404;
CC Q9NRQ5; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-8640191, EBI-2867874;
CC Q9NRQ5; P32942: ICAM3; NbExp=3; IntAct=EBI-8640191, EBI-725421;
CC Q9NRQ5; Q13651: IL10RA; NbExp=3; IntAct=EBI-8640191, EBI-1031656;
CC Q9NRQ5; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-8640191, EBI-749265;
CC Q9NRQ5; O95279: KCNK5; NbExp=3; IntAct=EBI-8640191, EBI-3934936;
CC Q9NRQ5; P43629: KIR3DL1; NbExp=3; IntAct=EBI-8640191, EBI-3910993;
CC Q9NRQ5; Q6A162: KRT40; NbExp=3; IntAct=EBI-8640191, EBI-10171697;
CC Q9NRQ5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-8640191, EBI-10172290;
CC Q9NRQ5; O95214: LEPROTL1; NbExp=3; IntAct=EBI-8640191, EBI-750776;
CC Q9NRQ5; Q8N386: LRRC25; NbExp=3; IntAct=EBI-8640191, EBI-11304917;
CC Q9NRQ5; P20645: M6PR; NbExp=3; IntAct=EBI-8640191, EBI-2907262;
CC Q9NRQ5; O14880: MGST3; NbExp=3; IntAct=EBI-8640191, EBI-724754;
CC Q9NRQ5; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-8640191, EBI-12806656;
CC Q9NRQ5; P15941-11: MUC1; NbExp=3; IntAct=EBI-8640191, EBI-17263240;
CC Q9NRQ5; O00623: PEX12; NbExp=3; IntAct=EBI-8640191, EBI-594836;
CC Q9NRQ5; Q8IV08: PLD3; NbExp=3; IntAct=EBI-8640191, EBI-2689908;
CC Q9NRQ5; O14684: PTGES; NbExp=3; IntAct=EBI-8640191, EBI-11161398;
CC Q9NRQ5; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-8640191, EBI-10192441;
CC Q9NRQ5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8640191, EBI-17247926;
CC Q9NRQ5; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-8640191, EBI-17595455;
CC Q9NRQ5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8640191, EBI-17295964;
CC Q9NRQ5; Q96GZ6: SLC41A3; NbExp=3; IntAct=EBI-8640191, EBI-7225508;
CC Q9NRQ5; P30825: SLC7A1; NbExp=3; IntAct=EBI-8640191, EBI-4289564;
CC Q9NRQ5; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-8640191, EBI-5235586;
CC Q9NRQ5; Q9BZL3: SMIM3; NbExp=5; IntAct=EBI-8640191, EBI-741850;
CC Q9NRQ5; O43278-2: SPINT1; NbExp=3; IntAct=EBI-8640191, EBI-12078338;
CC Q9NRQ5; P27105: STOM; NbExp=3; IntAct=EBI-8640191, EBI-1211440;
CC Q9NRQ5; Q96L08: SUSD3; NbExp=3; IntAct=EBI-8640191, EBI-18194029;
CC Q9NRQ5; Q8N205: SYNE4; NbExp=3; IntAct=EBI-8640191, EBI-7131783;
CC Q9NRQ5; Q8N205-2: SYNE4; NbExp=3; IntAct=EBI-8640191, EBI-12099160;
CC Q9NRQ5; Q8TBG9: SYNPR; NbExp=3; IntAct=EBI-8640191, EBI-10273251;
CC Q9NRQ5; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-8640191, EBI-19027521;
CC Q9NRQ5; O14948-3: TFEC; NbExp=3; IntAct=EBI-8640191, EBI-12246506;
CC Q9NRQ5; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-8640191, EBI-7238458;
CC Q9NRQ5; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-8640191, EBI-11742770;
CC Q9NRQ5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-8640191, EBI-6447886;
CC Q9NRQ5; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-8640191, EBI-744988;
CC Q9NRQ5; Q96G27: WBP1; NbExp=3; IntAct=EBI-8640191, EBI-3867685;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMCO4 family. {ECO:0000305}.
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DR EMBL; AF197137; AAF86046.1; -; mRNA.
DR EMBL; AP004242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031564; AAH31564.1; -; mRNA.
DR CCDS; CCDS8292.1; -.
DR RefSeq; NP_064564.1; NM_020179.2.
DR AlphaFoldDB; Q9NRQ5; -.
DR SMR; Q9NRQ5; -.
DR BioGRID; 121260; 59.
DR IntAct; Q9NRQ5; 56.
DR MINT; Q9NRQ5; -.
DR STRING; 9606.ENSP00000298966; -.
DR BioMuta; SMCO4; -.
DR DMDM; 74734326; -.
DR jPOST; Q9NRQ5; -.
DR MassIVE; Q9NRQ5; -.
DR PaxDb; Q9NRQ5; -.
DR PeptideAtlas; Q9NRQ5; -.
DR PRIDE; Q9NRQ5; -.
DR ProteomicsDB; 82405; -.
DR TopDownProteomics; Q9NRQ5; -.
DR Antibodypedia; 65692; 19 antibodies from 10 providers.
DR DNASU; 56935; -.
DR Ensembl; ENST00000298966.7; ENSP00000298966.2; ENSG00000166002.7.
DR Ensembl; ENST00000525141.1; ENSP00000431781.1; ENSG00000166002.7.
DR Ensembl; ENST00000527149.5; ENSP00000433555.1; ENSG00000166002.7.
DR Ensembl; ENST00000596676.2; ENSP00000479594.1; ENSG00000166002.7.
DR GeneID; 56935; -.
DR KEGG; hsa:56935; -.
DR MANE-Select; ENST00000298966.7; ENSP00000298966.2; NM_020179.3; NP_064564.1.
DR UCSC; uc001pds.5; human.
DR CTD; 56935; -.
DR DisGeNET; 56935; -.
DR GeneCards; SMCO4; -.
DR HGNC; HGNC:24810; SMCO4.
DR HPA; ENSG00000166002; Tissue enhanced (salivary).
DR MIM; 609477; gene.
DR neXtProt; NX_Q9NRQ5; -.
DR OpenTargets; ENSG00000166002; -.
DR PharmGKB; PA144596494; -.
DR VEuPathDB; HostDB:ENSG00000166002; -.
DR eggNOG; ENOG502S7F4; Eukaryota.
DR GeneTree; ENSGT00390000015987; -.
DR InParanoid; Q9NRQ5; -.
DR OMA; HEYLWTH; -.
DR OrthoDB; 365203at2759; -.
DR TreeFam; TF324415; -.
DR PathwayCommons; Q9NRQ5; -.
DR SignaLink; Q9NRQ5; -.
DR BioGRID-ORCS; 56935; 11 hits in 1069 CRISPR screens.
DR ChiTaRS; SMCO4; human.
DR GenomeRNAi; 56935; -.
DR Pharos; Q9NRQ5; Tdark.
DR PRO; PR:Q9NRQ5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NRQ5; protein.
DR Bgee; ENSG00000166002; Expressed in parotid gland and 173 other tissues.
DR ExpressionAtlas; Q9NRQ5; baseline and differential.
DR Genevisible; Q9NRQ5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027960; DUF4519.
DR PANTHER; PTHR34644; PTHR34644; 1.
DR Pfam; PF15012; DUF4519; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..59
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 4"
FT /id="PRO_0000087319"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..31
FT /evidence="ECO:0000255"
SQ SEQUENCE 59 AA; 6738 MW; 00D250C357495E73 CRC64;
MRQLKGKPKK ETSKDKKERK QAMQEARQQI TTVVLPTLAV VVLLIVVFVY VATRPTITE
