SMCO4_MOUSE
ID SMCO4_MOUSE Reviewed; 59 AA.
AC Q9JIS3; Q8VD32;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Single-pass membrane and coiled-coil domain-containing protein 4;
DE AltName: Full=Protein FN5;
GN Name=Smco4; Synonyms=Fn5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10863097; DOI=10.1016/s0378-1119(00)00188-8;
RA Kehrer-Sawatzki H., Moschgath E., Maier C., Legius E., Elgar G., Krone W.;
RT "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1
RT (Neurofibromatosis type 1) gene in the 5' direction and mapping of the
RT human counterparts.";
RL Gene 251:63-71(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=DBA/2J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMCO4 family. {ECO:0000305}.
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DR EMBL; AF197136; AAF86045.1; -; mRNA.
DR EMBL; AK146267; BAE27026.1; -; mRNA.
DR EMBL; BC017612; AAH17612.1; -; mRNA.
DR CCDS; CCDS22838.1; -.
DR RefSeq; NP_573477.2; NM_133214.2.
DR RefSeq; XP_011240710.1; XM_011242408.2.
DR RefSeq; XP_011240711.1; XM_011242409.2.
DR RefSeq; XP_011240713.1; XM_011242411.1.
DR AlphaFoldDB; Q9JIS3; -.
DR SMR; Q9JIS3; -.
DR STRING; 10090.ENSMUSP00000044228; -.
DR PaxDb; Q9JIS3; -.
DR PRIDE; Q9JIS3; -.
DR Antibodypedia; 65692; 19 antibodies from 10 providers.
DR Ensembl; ENSMUST00000045620; ENSMUSP00000044228; ENSMUSG00000058173.
DR Ensembl; ENSMUST00000178999; ENSMUSP00000136432; ENSMUSG00000058173.
DR Ensembl; ENSMUST00000215907; ENSMUSP00000150121; ENSMUSG00000058173.
DR GeneID; 170748; -.
DR KEGG; mmu:170748; -.
DR UCSC; uc009ogc.1; mouse.
DR CTD; 56935; -.
DR MGI; MGI:3039636; Smco4.
DR VEuPathDB; HostDB:ENSMUSG00000058173; -.
DR eggNOG; ENOG502S7F4; Eukaryota.
DR GeneTree; ENSGT00390000015987; -.
DR HOGENOM; CLU_209950_0_0_1; -.
DR InParanoid; Q9JIS3; -.
DR OMA; HEYLWTH; -.
DR OrthoDB; 1643635at2759; -.
DR TreeFam; TF324415; -.
DR BioGRID-ORCS; 170748; 2 hits in 69 CRISPR screens.
DR ChiTaRS; Smco4; mouse.
DR PRO; PR:Q9JIS3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9JIS3; protein.
DR Bgee; ENSMUSG00000058173; Expressed in animal zygote and 197 other tissues.
DR Genevisible; Q9JIS3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027960; DUF4519.
DR PANTHER; PTHR34644; PTHR34644; 1.
DR Pfam; PF15012; DUF4519; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..59
FT /note="Single-pass membrane and coiled-coil domain-
FT containing protein 4"
FT /id="PRO_0000087320"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..31
FT /evidence="ECO:0000255"
FT CONFLICT 20..21
FT /note="KQ -> NE (in Ref. 1; AAF86045)"
FT /evidence="ECO:0000305"
FT CONFLICT 28..29
FT /note="QQ -> HE (in Ref. 1; AAF86045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 59 AA; 6694 MW; 00D2424F27495E73 CRC64;
MRQLKGKPKK ETSKDKKERK QAMQEARQQI TTVVLPTLAV VVLLIVVFVY VATRPAVTE
