SMCR8_CAEEL
ID SMCR8_CAEEL Reviewed; 511 AA.
AC Q09346;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Guanine nucleotide exchange protein smcr-8 {ECO:0000305};
DE AltName: Full=Smith-Magenis syndrome chromosomal region 8 protein homolog {ECO:0000312|WormBase:R144.5};
GN Name=smcr-8 {ECO:0000312|WormBase:R144.5};
GN ORFNames=R144.5 {ECO:0000312|WormBase:R144.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Part of a complex that has guanine nucleotide exchange factor
CC (GEF) activity and regulates autophagy. {ECO:0000250|UniProtKB:Q8TEV9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TEV9}.
CC -!- SIMILARITY: Belongs to the SMCR8 family. {ECO:0000305}.
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DR EMBL; BX284603; CCD65874.1; -; Genomic_DNA.
DR PIR; T16752; T16752.
DR RefSeq; NP_498060.2; NM_065659.4.
DR AlphaFoldDB; Q09346; -.
DR BioGRID; 52578; 2.
DR STRING; 6239.R144.5; -.
DR EPD; Q09346; -.
DR PaxDb; Q09346; -.
DR PeptideAtlas; Q09346; -.
DR EnsemblMetazoa; R144.5.1; R144.5.1; WBGene00020095.
DR GeneID; 187901; -.
DR KEGG; cel:CELE_R144.5; -.
DR UCSC; R144.5; c. elegans.
DR CTD; 187901; -.
DR WormBase; R144.5; CE31581; WBGene00020095; smcr-8.
DR eggNOG; ENOG502QSW2; Eukaryota.
DR GeneTree; ENSGT00390000010052; -.
DR HOGENOM; CLU_533444_0_0_1; -.
DR InParanoid; Q09346; -.
DR OMA; AYLTNIC; -.
DR OrthoDB; 584950at2759; -.
DR PRO; PR:Q09346; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00020095; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR InterPro; IPR037521; FLCN/SMCR8_DENN.
DR PROSITE; PS51834; DENN_FLCN_SMCR8; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Guanine-nucleotide releasing factor;
KW Reference proteome.
FT CHAIN 1..511
FT /note="Guanine nucleotide exchange protein smcr-8"
FT /id="PRO_0000065441"
FT DOMAIN 20..168
FT /note="uDENN FLCN/SMCR8-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01178"
FT DOMAIN 282..425
FT /note="cDENN FLCN/SMCR8-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01178"
FT DOMAIN 434..488
FT /note="dDENN FLCN/SMCR8-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01178"
FT REGION 288..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 57335 MW; 3B5DEF8C41CDD4CD CRC64;
MISFEDFLLR PSKVVDPFNR FVAKIDPFLT LVEFCQVIGP KPLAVVSQRP DDKIRGVDIN
DMAIWLMSSD TVPGTMIVLE NNQTGVYAAA YYFNLYDMRA RAFQRNLCIA YLCSEKPTKE
TLNLFSSAMK KLVSPVLICN RRLFIRHVTD IVKFSDSVDE TTLKQYYTLN GDSQKLSDGS
RFNVVFEQTR LLKSKFLTKR FQEMAFDDDI CCGHNAENMN EAEDIICSFR VPSIPLSPVE
TLTPCAYSSI IPKLRQLCSE LCSSGSPNRN STHGALFCGH RPIATTSPAA TTTLPWNTDS
GKSDNDKNGE ETLKEVTGHL GDVIFPLLCG EDLVVCGAEQ RKSTVEDMLG KLSRVVPRES
ARNVEENIKI EKDPNRIGNG LGGLLCNRNE TGKLARWRNV LDMNRSALKT FTYDGSLLAG
LNKKRKFPSD RSLVLFIIAY LTNICQLAFI CRYMFIKSPN SIEKALGDQQ KLSSDDERIL
INLLMGIDFE KFNQLKVSSK DGAKPSRTIN L
