ID   BIK4_GIBF5              Reviewed;         326 AA.
AC   S0DZI6;
DT   08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Nitrogen metabolite regulation-like protein bik4 {ECO:0000305};
DE   AltName: Full=Bikaverin biosynthesis protein 4 {ECO:0000303|PubMed:19400779};
GN   Name=bik4 {ECO:0000303|PubMed:19400779}; ORFNames=FFUJ_06745;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19400779; DOI=10.1111/j.1365-2958.2009.06695.x;
RA   Wiemann P., Willmann A., Straeten M., Kleigrewe K., Beyer M., Humpf H.U.,
RA   Tudzynski B.;
RT   "Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes,
RT   their function and regulation.";
RL   Mol. Microbiol. 72:931-946(2009).
CC   -!- FUNCTION: Nitrogen metabolite regulation-like protein involved in the
CC       regulation of the gene cluster that mediates the biosynthesis of
CC       bikaverin, a red pigment also considered as a mycotoxin
CC       (PubMed:19400779). {ECO:0000269|PubMed:19400779}.
CC   -!- INDUCTION: Expression is repressed at alkaline ambient pH and highly
CC       induced under nitrogen starvation and acidic pH conditions
CC       (PubMed:19400779). {ECO:0000269|PubMed:19400779}.
CC   -!- DISRUPTION PHENOTYPE: Leads to decreased production of bikaverin
CC       (PubMed:19400779). {ECO:0000269|PubMed:19400779}.
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HF679027; CCT67994.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0DZI6; -.
DR   SMR; S0DZI6; -.
DR   EnsemblFungi; CCT67994; CCT67994; FFUJ_06745.
DR   VEuPathDB; FungiDB:FFUJ_06745; -.
DR   HOGENOM; CLU_007383_10_0_1; -.
DR   Proteomes; UP000016800; Chromosome 5.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008030; NmrA-like.
DR   Pfam; PF05368; NmrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NAD; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Nitrogen metabolite regulation-like protein bik4"
FT                   /id="PRO_0000436341"
FT   BINDING         13..18
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:Q5AU62"
FT   BINDING         161..164
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:Q5AU62"
SQ   SEQUENCE   326 AA;  35837 MW;  FC860D8879B16574 CRC64;
     MPSPHFSKVL VFGATGEVGS AVALEAHALG AHVSIALRDT TKHNEWISPS QEHAADLQRI
     SADLTDPDSL KRAVHDTGAQ AAFIYAVRSK DTLRGAITAL RDAGIQYLVF LSTSQVRTAG
     TTKGDIRSIK PDHFIPWQHA QVEIALEELE VPHAAVRAGF FASNPLRIYL DRSSEPKQVN
     LLAPEVPHDP IDPKDIGRAA AAVLVNPRLY ASGYQGEPKK DVVYLSGPAL LSQTEQWEII
     NRELVAAGKP EVKVNHITVE QYLENLAKLH VPDVVAKSLA KSMVETRALY APEDYEKSRG
     NVELLTGRKA TAFDEFVKRE IPRYFD