SMC_METCA
ID SMC_METCA Reviewed; 1169 AA.
AC Q604U6;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000255|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000255|HAMAP-Rule:MF_01894}; OrderedLocusNames=MCA2440;
OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylococcus.
OX NCBI_TaxID=243233;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33009 / NCIMB 11132 / Bath;
RX PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT "Genomic insights into methanotrophy: the complete genome sequence of
RT Methylococcus capsulatus (Bath).";
RL PLoS Biol. 2:1616-1628(2004).
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible SMC hinge
CC near the middle of the molecule. These domains are separated by coiled-
CC coil structures. {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. {ECO:0000255|HAMAP-
CC Rule:MF_01894}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAU91451.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE017282; AAU91451.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_041361299.1; NC_002977.6.
DR AlphaFoldDB; Q604U6; -.
DR SMR; Q604U6; -.
DR STRING; 243233.MCA2440; -.
DR PRIDE; Q604U6; -.
DR EnsemblBacteria; AAU91451; AAU91451; MCA2440.
DR KEGG; mca:MCA2440; -.
DR eggNOG; COG1196; Bacteria.
DR HOGENOM; CLU_001042_2_2_6; -.
DR OrthoDB; 1149850at2; -.
DR Proteomes; UP000006821; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF75553; SSF75553; 1.
DR TIGRFAMs; TIGR02168; SMC_prok_B; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1169
FT /note="Chromosome partition protein Smc"
FT /id="PRO_0000409276"
FT DOMAIN 525..620
FT /note="SMC hinge"
FT COILED 170..265
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 307..481
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 656..914
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 985..1014
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1169 AA; 130652 MW; 625B37A536E390AF CRC64;
MRLEKLKIAG FKSFVDPTTL PLPGNLVGVV GPNGCGKSNV IDAVRWVMGE SSARHLRGET
MADVIFNGSS TRKPASQASV ELVFDNSSGR AGGEYARYQQ IAIRRQVARD GQSSYFLNGT
RCRRKDITDL FLGTGLGARS YAIIEQGTIS RLIEAKPEEM REIIEEAAGI SKYKERRHET
EQRMRHTREN LERLADLREE LGRQLGHLQR QARKAEKFIA LRDEERRLKL ELLGLRWRAL
ERQLDRLKAE LTDSEERFRR LTGEEHACET QLEGLNRLRG VAQEKLDVQQ GRFYELGAEI
SRLDQFIRHT QKSRAELVQE RERVEAELRK VESDRDDDRL RLEAVRAEAA ELKGKLASLE
QEVAEAVSVR QAAEAKLKTC REGWEALAGD RHRLEGQAAL QRSRLQQLRE HGQQLGGRRQ
RLLQQQSELE KALAALDVQA HRLEVAGIEA EREETVGAVE ALAREAERQR DRLRFARERL
NPARAGLHAV QGKVASLETL QRHAMGRDRS AAAAVLEAWQ LSAADRLGEK IEVAPGWENA
VETVLGAHLE AVCVDSLAPY LANLQAQEPA EFLALCEYRQ GPVAEGTGGP RLLDYIRAPL
ALEGLLAGIY CASDPAEAAE RARSLQPHES VVTPGGFRIG KGWVLAQKPD AGHAGALARE
RELRECRRRV EELEAQCRIL EREASEAEVE LERLESEGRE ARKKADELSA GLSLARSELA
AAEARSEQWR HRLDQLSHEL NELADQELEL AEKRAEAEEA LQTAERDSLR LQDVAAQRKG
EWLALEEAFA AAEAAEKSLH EEVRALRSRA AMLESNAALT AAHLQRLEQQ HGQTADRLAA
IVQRLAESQT PLEDERSRLD ALTEERGVLE AEMARQRRRL SELEADVRRV AGERQRAEHE
LAALRESIGQ MKLAWQTAEV RRQGIEEQFA ELGAAPAAVV AGLPEDAEES AWQASVIRLG
EEIERLGPVN LTAMQEYQEQ EARQRYLEEQ DRDLTESLAT LEQAIEKIDR ECRARFKETF
EKINAGFQRM FPKLFGGGKA ALELTENNLL SAGVSVMAQP PGKRNSSIHL LSGGEKALTA
AALVFAIFEL NPAPFCLLDE VDAPLDDANV GRFSQLVKEM SEKVQFLFIT HNKATMEIAQ
YLAGVTMREP GVSRIVTVDI DAAVELASV
