SMC_MYCLE
ID SMC_MYCLE Reviewed; 1203 AA.
AC Q9CBT5; Q9X7D0;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000255|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000255|HAMAP-Rule:MF_01894}; OrderedLocusNames=ML1629;
GN ORFNames=MLCB250.01;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible SMC hinge
CC near the middle of the molecule. These domains are separated by coiled-
CC coil structures. {ECO:0000255|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. {ECO:0000255|HAMAP-
CC Rule:MF_01894}.
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DR EMBL; AL583922; CAC30580.1; -; Genomic_DNA.
DR EMBL; Z97369; CAB10595.1; -; Genomic_DNA.
DR PIR; G87112; G87112.
DR RefSeq; NP_302121.1; NC_002677.1.
DR RefSeq; WP_010908442.1; NC_002677.1.
DR AlphaFoldDB; Q9CBT5; -.
DR SMR; Q9CBT5; -.
DR STRING; 272631.ML1629; -.
DR EnsemblBacteria; CAC30580; CAC30580; CAC30580.
DR KEGG; mle:ML1629; -.
DR PATRIC; fig|272631.5.peg.3070; -.
DR Leproma; ML1629; -.
DR eggNOG; COG1196; Bacteria.
DR HOGENOM; CLU_001042_2_0_11; -.
DR OMA; HNKIAME; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF75553; SSF75553; 1.
DR TIGRFAMs; TIGR02168; SMC_prok_B; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1203
FT /note="Chromosome partition protein Smc"
FT /id="PRO_0000119029"
FT DOMAIN 511..622
FT /note="SMC hinge"
FT COILED 167..203
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 250..288
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 327..497
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 657..689
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 720..765
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT COILED 976..1030
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1203 AA; 131027 MW; A0B0FB6E41B4075A CRC64;
MYLKSLTLKG FKSFASPTTL RFEPGITAVV GPNGSGKSNV VDALAWVMGE QGAKTLRGSK
MEDVIFAGTL SRAPLGRAEV TLIIDNSDNV LPIEYSEVSI TRRMFRDGAS EYEINGSSCR
LMDVQELLSD SGIGREMHVI VGQGKLDQIL QSRPEDRRTF IEEAAGILKY RRRKEKALRK
LDAMSANLAR LTDLTTELRR QLKPLSRQAE VARRAATIQA DLRDARLRLA ADDLVSRQGQ
RDAIVEAETM MRRDHDEAAA RLAVASEELA AHEAALTELS GRAESVQQIW FGLSTLVERV
SATIRIAGER AYHLDVDPAT PSDTDPDVLE AEAQQMEVAE QQLLAELAVA RTQLEAARAE
LADRERHAVE ADKAHLEAVR AEADRREGLA LLAGQVETMR ARIESIDDSV ARLSERIEEV
TARTQQILAE FETVQGRVGE LDQSEVHLDE QHERAVAALR FANERVAELQ SAERDAERQV
VSLRARIDAL TMGLERKDGA AWLARNYSDT GLLGSIAKLV KVRPGYEAAL AAVLGPAADA
LAVDSLGAAR SALTALKEAD AGRATLVLAD WLADAGPACV TGLPDGAQRA LDLIEAPPWL
QGALIAMLYG VVVVNYLAEA LGVVDICPQL RVVTVDGDLV GAGWVSGGSG RRLSTLEVTS
EIDKAGAELA AAEAHMAQLN AALSGALSEQ VAHSDATEQA LVALNESDTA ILSMYDQLGR
LGQEVRAAEA EWESLLAQRE ELEARRVSIL EEVVELETRL HNVEQIQHVH ALDENSAAAR
QLIVAAAEEA RGVEVEALLA VRTAEERVNA VCGRANSLRR AAAAEREVRL RDQQAHAARI
RAAAVAAAVT DCGQLLASRL TQAVDLAARH RDALATERQQ RSVAIAAVRY EVNTLRVRLA
TLTDSLHRDE VANVQAALRI EQLEQLVLEQ FGIAPVDLIA EYGPQVALLP TELEMAEFQQ
ARERGEQVTS PAPMPYDRAT QERRAKRAER ELAELGRVNP LALEEFAALE ERYNFLSTQL
EDVKGARKDL LDVVAEVDAR ILQVFSDAFV DVEREFRGVF TSLFPGGEGR LRLTDPDDML
TTGIEVEARP SGKKVSRLSL LSGGEKSLIA VAMLVAIFKA RPSPFYIMDE VEAALDDVNL
CRLIGVFEQL RGQSQLIIIT HQKPTMEVAD TLYGVTMQGD GITAVISQRM RGQQVESLVT
SSS
