ID   BIK5_GIBF5              Reviewed;         743 AA.
AC   S0E028;
DT   08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Bikaverin cluster transcription factor bik5 {ECO:0000305};
DE   AltName: Full=Bikaverin biosynthesis protein 5 {ECO:0000303|PubMed:19400779};
GN   Name=bik5 {ECO:0000303|PubMed:19400779}; ORFNames=FFUJ_06746;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19400779; DOI=10.1111/j.1365-2958.2009.06695.x;
RA   Wiemann P., Willmann A., Straeten M., Kleigrewe K., Beyer M., Humpf H.U.,
RA   Tudzynski B.;
RT   "Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes,
RT   their function and regulation.";
RL   Mol. Microbiol. 72:931-946(2009).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of bikaverin, a red pigment
CC       also considered as a mycotoxin (PubMed:19400779).
CC       {ECO:0000269|PubMed:19400779}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is repressed by glutamine and at alkaline ambient
CC       pH and highly induced under nitrogen starvation and acidic pH
CC       conditions (PubMed:19400779). {ECO:0000269|PubMed:19400779}.
CC   -!- DISRUPTION PHENOTYPE: Leads to decreased production of bikaverin
CC       (PubMed:19400779). {ECO:0000269|PubMed:19400779}.
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DR   EMBL; HF679027; CCT67995.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0E028; -.
DR   PRIDE; S0E028; -.
DR   EnsemblFungi; CCT67995; CCT67995; FFUJ_06746.
DR   VEuPathDB; FungiDB:FFUJ_06746; -.
DR   HOGENOM; CLU_004083_7_3_1; -.
DR   Proteomes; UP000016800; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..743
FT                   /note="Bikaverin cluster transcription factor bik5"
FT                   /id="PRO_0000436342"
FT   DNA_BIND        23..50
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          421..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..445
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  83282 MW;  2BA3E3BCB743F628 CRC64;
     MDSALGNLSM PGLAQSHVQV RTCIHCRQRR VKCDRQFPQC SNCIRSEVNC IYPPGRGRAP
     KRPKRSLAPQ LSERLSRLES IIGQFGAAAR ENQDTPQTAQ DSEGHSFEQD FSRLKVDESK
     SYYVNNALWV EELRDLLFEP ASEDAGYEPS ISSSATTAAT SPSSPQLGLN AAIFGYRAIA
     SPLYHYHPSL QQAVTLFAAF SENVAPLVRI FHMPTLTRIY WDAIASLGTV DKHTETLLFT
     IHYSAVISLN PEQCLNILDE TREAALERYR FAVEQALAQG NLLSTQSMTM LQAAVLFLSA
     LPNEDDSRAA WALTSLVFHI ARTMGLHRDG TIFGLKPFET ELRRRLWWQI CIIDSRSSEY
     HCNEPIAQGF ITDTKPPLHI NDVDLSPEMV EPPAERWDHA TDMTLTLVRC EAIQTGLKLG
     RMRHKQNKTS EDGSTPRVDD TSDTPKTLIQ ELESRLRDKY LPICDTSVPF QLLSSAVAQI
     ILGRFWLITQ YSVVSREREV DGKSTSNQFP PTPNTAGQLD NKVRDELFQT SIKILEVSGM
     LLTSKEIIQF TWYSKTHIQW GAMAFVLSEL CARPQSAQCD QAWDCVTTVY EGWKVDESKQ
     DETRLALWRP IKRLMAKARY VKEMQQTTPG RSSNAGRKVQ RRDPVLYSPS PGLFSQYPTP
     AYSNNWYGPL QQTPPSIPGS EASLPGMATV PLDSSGQSDA LQRVLGTETL GPFMDMIPEW
     PWVDAEHGAS SLAGFDLGLP RFN