SMD1_CAEEL
ID SMD1_CAEEL Reviewed; 126 AA.
AC Q10013;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable small nuclear ribonucleoprotein Sm D1;
DE Short=Sm-D1;
DE AltName: Full=snRNP core protein D1;
GN Name=snr-3; ORFNames=T28D9.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome (By similarity).
CC {ECO:0000250|UniProtKB:P62314}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62314}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62314}.
CC -!- SIMILARITY: Belongs to the snRNP core protein family. {ECO:0000305}.
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DR EMBL; FO081595; CCD72707.1; -; Genomic_DNA.
DR PIR; T16952; T16952.
DR RefSeq; NP_495306.1; NM_062905.4.
DR AlphaFoldDB; Q10013; -.
DR SMR; Q10013; -.
DR BioGRID; 39411; 45.
DR IntAct; Q10013; 2.
DR STRING; 6239.T28D9.10a; -.
DR EPD; Q10013; -.
DR PaxDb; Q10013; -.
DR PeptideAtlas; Q10013; -.
DR EnsemblMetazoa; T28D9.10a.1; T28D9.10a.1; WBGene00004916.
DR GeneID; 174072; -.
DR KEGG; cel:CELE_T28D9.10; -.
DR UCSC; T28D9.10.1; c. elegans.
DR CTD; 174072; -.
DR WormBase; T28D9.10a; CE02065; WBGene00004916; snr-3.
DR eggNOG; KOG3428; Eukaryota.
DR GeneTree; ENSGT00510000047245; -.
DR HOGENOM; CLU_123956_3_0_1; -.
DR InParanoid; Q10013; -.
DR OMA; SVTPQMN; -.
DR OrthoDB; 1579192at2759; -.
DR PhylomeDB; Q10013; -.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q10013; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004916; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q10013; baseline and differential.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000243; C:commitment complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043186; C:P granule; IDA:WormBase.
DR GO; GO:0034715; C:pICln-Sm protein complex; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0034719; C:SMN-Sm protein complex; IBA:GO_Central.
DR GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR CDD; cd01724; Sm_D1; 1.
DR InterPro; IPR027141; LSm4/Sm_D1/D3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034102; Sm_D1.
DR PANTHER; PTHR23338; PTHR23338; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; Spliceosome.
FT CHAIN 1..126
FT /note="Probable small nuclear ribonucleoprotein Sm D1"
FT /id="PRO_0000122203"
FT REGION 86..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 126 AA; 13625 MW; 24D266C7FA9DBD65 CRC64;
MKLVRFLMKL SHETVNIELK NGTQVSGTIM GVDVAMNTHL RAVSMTVKNK EPVKLDTLSI
RGNNIRYIIL PDPLALDTLL IDDEPRKKAR AARAGASRGR GRGGMRGGRG GRGRGRGGPR
GGGPRR
