SMD2_CAEEL
ID SMD2_CAEEL Reviewed; 118 AA.
AC Q18786;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable small nuclear ribonucleoprotein Sm D2;
DE Short=Sm-D2;
DE AltName: Full=snRNP core protein D2;
GN Name=snr-4; ORFNames=C52E4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome.
CC {ECO:0000250|UniProtKB:P62316}.
CC -!- INTERACTION:
CC Q18786; P34659: snr-5; NbExp=4; IntAct=EBI-327286, EBI-328740;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62316}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62316}.
CC -!- SIMILARITY: Belongs to the snRNP core protein family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z78012; CAB01413.1; -; Genomic_DNA.
DR PIR; T20151; T20151.
DR RefSeq; NP_506004.1; NM_073603.5.
DR AlphaFoldDB; Q18786; -.
DR SMR; Q18786; -.
DR BioGRID; 44663; 37.
DR DIP; DIP-27008N; -.
DR IntAct; Q18786; 1.
DR STRING; 6239.C52E4.3.1; -.
DR EPD; Q18786; -.
DR PaxDb; Q18786; -.
DR PeptideAtlas; Q18786; -.
DR EnsemblMetazoa; C52E4.3.1; C52E4.3.1; WBGene00004917.
DR GeneID; 179639; -.
DR KEGG; cel:CELE_C52E4.3; -.
DR UCSC; C52E4.3.2; c. elegans.
DR CTD; 179639; -.
DR WormBase; C52E4.3; CE08945; WBGene00004917; snr-4.
DR eggNOG; KOG3459; Eukaryota.
DR GeneTree; ENSGT00390000017608; -.
DR HOGENOM; CLU_076902_2_2_1; -.
DR InParanoid; Q18786; -.
DR OMA; GPMSLIN; -.
DR OrthoDB; 1581611at2759; -.
DR PhylomeDB; Q18786; -.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q18786; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00004917; Expressed in embryo and 4 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR CDD; cd01720; Sm_D2; 1.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR027248; Sm_D2.
DR PANTHER; PTHR12777; PTHR12777; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; Spliceosome.
FT CHAIN 1..118
FT /note="Probable small nuclear ribonucleoprotein Sm D2"
FT /id="PRO_0000122210"
SQ SEQUENCE 118 AA; 13267 MW; 24773D272A1D1555 CRC64;
MSAQAKPRSE MTAEELAAKE DEEFNVGPLS ILTNSVKNNH QVLINCRNNK KLLGRVKAFD
RHCNMVLENV KEMWTEVPKT GKGKKKAKSV AKDRFISKMF LRGDSVILVV KNPLAQAE
