SMD3_CAEEL
ID SMD3_CAEEL Reviewed; 136 AA.
AC Q17348; Q9U2U5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Small nuclear ribonucleoprotein Sm D3;
DE Short=Sm-D3;
DE AltName: Full=snRNP core protein D3;
GN Name=snr-1; ORFNames=Y116A8C.42;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-85.
RA Winge P.;
RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome (By similarity).
CC {ECO:0000250|UniProtKB:P62318}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62318}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}.
CC -!- SIMILARITY: Belongs to the snRNP core protein family. {ECO:0000305}.
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DR EMBL; AL117204; CAB55132.1; -; Genomic_DNA.
DR EMBL; U23937; AAA65451.1; -; mRNA.
DR PIR; T31498; T31498.
DR RefSeq; NP_503027.1; NM_070626.4.
DR AlphaFoldDB; Q17348; -.
DR SMR; Q17348; -.
DR BioGRID; 43560; 54.
DR IntAct; Q17348; 1.
DR STRING; 6239.Y116A8C.42; -.
DR EPD; Q17348; -.
DR PaxDb; Q17348; -.
DR PeptideAtlas; Q17348; -.
DR EnsemblMetazoa; Y116A8C.42.1; Y116A8C.42.1; WBGene00004914.
DR GeneID; 178483; -.
DR KEGG; cel:CELE_Y116A8C.42; -.
DR UCSC; Y116A8C.42.1; c. elegans.
DR CTD; 178483; -.
DR WormBase; Y116A8C.42; CE23346; WBGene00004914; snr-1.
DR eggNOG; KOG3172; Eukaryota.
DR GeneTree; ENSGT00610000086153; -.
DR HOGENOM; CLU_099537_1_0_1; -.
DR InParanoid; Q17348; -.
DR OMA; MNCQLRD; -.
DR OrthoDB; 1584810at2759; -.
DR PhylomeDB; Q17348; -.
DR Reactome; R-CEL-111367; SLBP independent Processing of Histone Pre-mRNAs.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-77588; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
DR PRO; PR:Q17348; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004914; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000243; C:commitment complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043186; C:P granule; IDA:WormBase.
DR GO; GO:0034715; C:pICln-Sm protein complex; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0034719; C:SMN-Sm protein complex; IBA:GO_Central.
DR GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR CDD; cd01721; Sm_D3; 1.
DR InterPro; IPR027141; LSm4/Sm_D1/D3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034099; SmD3.
DR PANTHER; PTHR23338; PTHR23338; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; Spliceosome.
FT CHAIN 1..136
FT /note="Small nuclear ribonucleoprotein Sm D3"
FT /id="PRO_0000122217"
FT REGION 98..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 15..16
FT /note="EG -> RS (in Ref. 2; AAA65451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 14812 MW; B0424DD28CB84E8C CRC64;
MTSVGVPIKI LHEAEGHMVT LETVTGEVYR GKLSEAEDNM NCQLAETVVT FRDGRSHQLD
NVFIRGNKIR FMILPDMLKN APMFKNIGRA QKGAIGMGLG GLDQRGRGRG TAFRRPMGRG
GPRGMSRPGG APTFRG
