SMD3_XENLA
ID SMD3_XENLA Reviewed; 126 AA.
AC P62323;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Small nuclear ribonucleoprotein Sm D3;
DE Short=Sm-D3;
DE AltName: Full=snRNP core protein D3;
GN Name=snrpd3;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome. Component of both the
CC pre-catalytic spliceosome B complex and activated spliceosome C
CC complexes. Is also a component of the minor U12 spliceosome (By
CC similarity). As part of the U7 snRNP it is involved in histone pre-mRNA
CC 3'-end processing (By similarity). {ECO:0000250|UniProtKB:P62318,
CC ECO:0000250|UniProtKB:P62320}.
CC -!- SUBUNIT: Core component of the spliceosomal U1, U2, U4 and U5 small
CC nuclear ribonucleoproteins (snRNPs), the building blocks of the
CC spliceosome. Most spliceosomal snRNPs contain a common set of Sm
CC proteins, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that
CC assemble in a heptameric protein ring on the Sm site of the small
CC nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1
CC snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb,
CC snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg, and at least three U1
CC snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C.
CC Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and
CC U5 snRNAs and at least prpf3, prpf4, prpf6, prpf8, prpf31, snrnp200,
CC txnl4a, snrnp40, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf, snrpg,
CC ddx23, cd2bp2, ppih, snu13, eftud2, sart1 and usp39, plus lsm2, lsm3,
CC lsm4, lsm5, lsm6, lsm7 and lsm8. Component of the U7 snRNP complex, or
CC U7 Sm protein core complex, that is composed of the U7 snRNA and at
CC least lsm10, lsm11, snrpb, snrpd3, snrpe, snrpf and snrpg; the complex
CC does not contain snrpd1 and snrpd2. Component of the U11/U12 snRNPs
CC that are part of the U12-type spliceosome. Part of the SMN-Sm complex
CC that contains smn1, gemin2/sip1, ddx20/gemin3, gemin4, gemin5, gemin6,
CC gemin7, gemin8, strap/unrip and the Sm proteins snrpb, snrpd1, snrpd2,
CC snrpd3, snrpe, snrpf and snrpg; catalyzes core snRNPs assembly. Forms a
CC 6S pICln-Sm complex composed of clns1a/pICln, snrpd1, snrpd2, snrpe,
CC snrpf and snrpg; ring-like structure where clns1a/pICln mimics
CC additional Sm proteins and which is unable to assemble into the core
CC snRNP. {ECO:0000250|UniProtKB:P62318}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P62318}. Nucleus {ECO:0000250|UniProtKB:P62318}.
CC Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC before SMN-mediated transport to the nucleus to be included in
CC spliceosomes. {ECO:0000250|UniProtKB:P62318}.
CC -!- PTM: Methylated on arginine residues by PRMT5 and PRMT7; probable
CC asymmetric dimethylation which is required for assembly and biogenesis
CC of snRNPs. {ECO:0000250|UniProtKB:P62318}.
CC -!- SIMILARITY: Belongs to the snRNP core protein family. {ECO:0000305}.
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DR EMBL; BC070616; AAH70616.1; -; mRNA.
DR RefSeq; NP_001084936.1; NM_001091467.1.
DR AlphaFoldDB; P62323; -.
DR SMR; P62323; -.
DR BioGRID; 101359; 1.
DR MaxQB; P62323; -.
DR DNASU; 431993; -.
DR GeneID; 431993; -.
DR KEGG; xla:431993; -.
DR CTD; 431993; -.
DR Xenbase; XB-GENE-1014508; snrpd3.L.
DR OMA; MNCQLRD; -.
DR OrthoDB; 1584810at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 431993; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0034709; C:methylosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0034715; C:pICln-Sm protein complex; ISS:UniProtKB.
DR GO; GO:0034719; C:SMN-Sm protein complex; ISS:UniProtKB.
DR GO; GO:0005685; C:U1 snRNP; ISS:UniProtKB.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0005687; C:U4 snRNP; ISS:UniProtKB.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR GO; GO:0071208; F:histone pre-mRNA DCP binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; ISS:UniProtKB.
DR CDD; cd01721; Sm_D3; 1.
DR DisProt; DP01707; -.
DR InterPro; IPR027141; LSm4/Sm_D1/D3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034099; SmD3.
DR PANTHER; PTHR23338; PTHR23338; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Methylation; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..126
FT /note="Small nuclear ribonucleoprotein Sm D3"
FT /id="PRO_0000122216"
FT REPEAT 110..111
FT /note="1"
FT REPEAT 112..113
FT /note="2"
FT REPEAT 114..115
FT /note="3"
FT REPEAT 116..117
FT /note="4"
FT REPEAT 118..119
FT /note="5"
FT REGION 110..119
FT /note="5 X 2 AA tandem repeats of [RM]-G"
SQ SEQUENCE 126 AA; 13916 MW; 59A6E78E860AA3E0 CRC64;
MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ
VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN
IFQKRR
