ID   SMDC1_MOUSE             Reviewed;         188 AA.
AC   Q8K190;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=SAYSvFN domain-containing protein 1;
GN   Name=Saysd1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
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DR   EMBL; BC027644; AAH27644.1; -; mRNA.
DR   CCDS; CCDS49406.1; -.
DR   RefSeq; NP_080485.1; NM_026209.1.
DR   AlphaFoldDB; Q8K190; -.
DR   BioGRID; 212237; 2.
DR   STRING; 10090.ENSMUSP00000055382; -.
DR   iPTMnet; Q8K190; -.
DR   PhosphoSitePlus; Q8K190; -.
DR   EPD; Q8K190; -.
DR   jPOST; Q8K190; -.
DR   MaxQB; Q8K190; -.
DR   PaxDb; Q8K190; -.
DR   PeptideAtlas; Q8K190; -.
DR   PRIDE; Q8K190; -.
DR   ProteomicsDB; 257521; -.
DR   Antibodypedia; 2340; 111 antibodies from 16 providers.
DR   Ensembl; ENSMUST00000059666; ENSMUSP00000055382; ENSMUSG00000045107.
DR   GeneID; 67509; -.
DR   KEGG; mmu:67509; -.
DR   UCSC; uc007siy.2; mouse.
DR   CTD; 55776; -.
DR   MGI; MGI:1914759; Saysd1.
DR   VEuPathDB; HostDB:ENSMUSG00000045107; -.
DR   eggNOG; KOG3249; Eukaryota.
DR   GeneTree; ENSGT00390000004313; -.
DR   HOGENOM; CLU_114258_0_0_1; -.
DR   InParanoid; Q8K190; -.
DR   OMA; QGEKSAY; -.
DR   OrthoDB; 1476036at2759; -.
DR   PhylomeDB; Q8K190; -.
DR   TreeFam; TF106140; -.
DR   BioGRID-ORCS; 67509; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Saysd1; mouse.
DR   PRO; PR:Q8K190; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8K190; protein.
DR   Bgee; ENSMUSG00000045107; Expressed in seminiferous tubule of testis and 229 other tissues.
DR   Genevisible; Q8K190; MM.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   InterPro; IPR039159; SAYSD1.
DR   InterPro; IPR019387; Uncharacterised_SAYSvFN.
DR   PANTHER; PTHR13527; PTHR13527; 1.
DR   Pfam; PF10260; SAYSvFN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="SAYSvFN domain-containing protein 1"
FT                   /id="PRO_0000089518"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   188 AA;  20704 MW;  2CD7E8350B1B7549 CRC64;
     MEQRLAEFRE ARKRASLVAQ PSTSSQSVQT SGAKAEPAAA TPKTATGWLT RFLKRKANPA
     IAQAQPNQPQ EAGQQLPEST AVPLPSSCRQ SFLTNITFLK VLLWLVLLGL FVELEFGLAY
     FVLSMFYWMY VGTRGPEEKK EGEKSAYSVF NPGCEAIQGT LTAEQLEQEL QLRPPQGSRT
     SPSCSSYP