ID   SMDL_DICDI              Reviewed;         257 AA.
AC   Q54HH8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Small nuclear ribonucleoprotein Sm D-like protein;
GN   ORFNames=DDB_G0289453;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for pre-mRNA splicing. Required for snRNP biogenesis
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the snRNP core protein family. {ECO:0000305}.
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DR   EMBL; AAFI02000141; EAL62706.1; -; Genomic_DNA.
DR   RefSeq; XP_636207.1; XM_631115.1.
DR   AlphaFoldDB; Q54HH8; -.
DR   SMR; Q54HH8; -.
DR   STRING; 44689.DDB0233195; -.
DR   PaxDb; Q54HH8; -.
DR   EnsemblProtists; EAL62706; EAL62706; DDB_G0289453.
DR   GeneID; 8627145; -.
DR   KEGG; ddi:DDB_G0289453; -.
DR   dictyBase; DDB_G0289453; -.
DR   eggNOG; ENOG502QS1B; Eukaryota.
DR   HOGENOM; CLU_085833_0_0_1; -.
DR   InParanoid; Q54HH8; -.
DR   OMA; DNLNKCR; -.
DR   Reactome; R-DDI-430039; mRNA decay by 5' to 3' exoribonuclease.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q54HH8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR040002; Sm-like_LSM3.
DR   PANTHER; PTHR13110; PTHR13110; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein.
FT   CHAIN           1..257
FT                   /note="Small nuclear ribonucleoprotein Sm D-like protein"
FT                   /id="PRO_0000328301"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28652 MW;  A9A9EA24338F6597 CRC64;
     MDNLKSKNKG NGGGDHDNYG NDNDKFNVLS DKFDALLALK NPQLVSLPFP KIKPLDNIHK
     ARILLPPSDE NYVQIKKPPT QPINNINITS LNNNNSSTTT NTSPPIESTP TTTTTTTTTT
     TTSTTSTNSI ASIVETTTTT TTIRKKNTNE DHKILKNISN KFTDGPLSLL KRALESKSKI
     KVMIRGTNCI RGYCRGYIIA FDKHMNIILR DVEEEYDLLK SLPSTRNQNQ PIQPKIKRYY
     GQLFIKGDTV VSVILID