ID   SMER_SERMA              Reviewed;         292 AA.
AC   P52683;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Carbapenem-hydrolyzing beta-lactamase transcriptional activator;
GN   Name=smeR; Synonyms=bplR;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S6;
RX   PubMed=7793864; DOI=10.1128/aac.39.3.629;
RA   Naas T., Livermore D.M., Nordmann P.;
RT   "Characterization of an LysR family protein, SmeR from Serratia marcescens
RT   S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase
RT   Sme-1, and comparison of this regulator with other beta-lactamase
RT   regulators.";
RL   Antimicrob. Agents Chemother. 39:629-637(1995).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression of
CC       carbapenem-hydrolyzing beta-lactamase (smeA). Seems to also be a
CC       repressor of its own transcription.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; Z30237; CAA82943.1; -; Genomic_DNA.
DR   PIR; S49164; S49164.
DR   AlphaFoldDB; P52683; -.
DR   SMR; P52683; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..292
FT                   /note="Carbapenem-hydrolyzing beta-lactamase
FT                   transcriptional activator"
FT                   /id="PRO_0000105693"
FT   DOMAIN          5..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   292 AA;  33034 MW;  EB79D50419DDC1CF CRC64;
     MKNRIPLNAL RAFEASARYL NFTKAGLELH VSQAAVSQHV RTLEAILGVN LFKRLPRGLQ
     LTEEGLHLLP MINEAFSIMG SALERFHEGK IREVITVAVV GTFAVGWLLP RLSGFTKSYP
     WIDIRVITHN NVINLAAEGI DAAIRFGHGF WQSTENYKLF SAPHTVLCPP NVAKKLTTPE
     DMKDYRLLRT YRKEEWSSWF KAANLKPWPV TGPIFDSSRH MDDAAKICGD IALAPYKMFI
     HEIENGSLVK PFDIEVHLGG YWLTILKSRS NIELNNALNI FKTWLLNASH SI