ID   SMF1_STRMK              Reviewed;         169 AA.
AC   B2FNJ0;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Major fimbrial subunit SMF-1 {ECO:0000305};
DE   AltName: Full=S. maltophilia fimbriae 1 {ECO:0000303|PubMed:12925132};
DE            Short=SMF-1 {ECO:0000303|PubMed:12925132};
DE   Flags: Precursor;
GN   Name=smf-1 {ECO:0000312|EMBL:CAQ44285.1};
GN   OrderedLocusNames=Smlt0706 {ECO:0000312|EMBL:CAQ44285.1};
OS   Stenotrophomonas maltophilia (strain K279a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=522373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K279a;
RX   PubMed=18419807; DOI=10.1186/gb-2008-9-4-r74;
RA   Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A.,
RA   Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E.,
RA   Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S.,
RA   Quail M.A., Rajandream M.A., Harris D., Churcher C., Bentley S.D.,
RA   Parkhill J., Thomson N.R., Avison M.B.;
RT   "The complete genome, comparative and functional analysis of
RT   Stenotrophomonas maltophilia reveals an organism heavily shielded by drug
RT   resistance determinants.";
RL   Genome Biol. 9:R74.1-R74.13(2008).
RN   [2]
RP   PROTEIN SEQUENCE OF 12-29, FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=ATCC 13637, and SMDP92;
RX   PubMed=12925132; DOI=10.1046/j.1462-5822.2003.00306.x;
RA   de Oliveira-Garcia D., Dall'Agnol M., Rosales M., Azzuz A.C., Alcantara N.,
RA   Martinez M.B., Giron J.A.;
RT   "Fimbriae and adherence of Stenotrophomonas maltophilia to epithelial cells
RT   and to abiotic surfaces.";
RL   Cell. Microbiol. 5:625-636(2003).
RN   [3]
RP   DISTRIBUTION IN STRAINS.
RX   PubMed=20952251; DOI=10.1016/j.ijmm.2010.07.003;
RA   Nicoletti M., Iacobino A., Prosseda G., Fiscarelli E., Zarrilli R.,
RA   De Carolis E., Petrucca A., Nencioni L., Colonna B., Casalino M.;
RT   "Stenotrophomonas maltophilia strains from cystic fibrosis patients:
RT   genomic variability and molecular characterization of some virulence
RT   determinants.";
RL   Int. J. Med. Microbiol. 301:34-43(2011).
CC   -!- FUNCTION: Involved in adherence to eukaryotic epithelial cells and
CC       abiotic surfaces. Mediates agglutination of animal red blood cells.
CC       {ECO:0000269|PubMed:12925132}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:12925132}.
CC   -!- INDUCTION: Expression is temperature-dependent. Expression is maximal
CC       between 30-37 degrees Celsius. Not expressed at 18 degrees Celsius.
CC       {ECO:0000269|PubMed:12925132}.
CC   -!- MISCELLANEOUS: The smf-1 gene is present in clinically derived strains,
CC       including strains isolated from hospital environment, but not in
CC       strains of environmental origin. {ECO:0000305|PubMed:20952251}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; AM743169; CAQ44285.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2FNJ0; -.
DR   SMR; B2FNJ0; -.
DR   STRING; 522373.Smlt0706; -.
DR   EnsemblBacteria; CAQ44285; CAQ44285; Smlt0706.
DR   KEGG; sml:Smlt0706; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_2_4_6; -.
DR   OMA; IENTCTV; -.
DR   Proteomes; UP000008840; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR039458; FimA-like.
DR   Pfam; PF16970; FimA; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Direct protein sequencing; Fimbrium; Reference proteome;
KW   Signal; Virulence.
FT   SIGNAL          1..11
FT                   /evidence="ECO:0000269|PubMed:12925132"
FT   CHAIN           12..169
FT                   /note="Major fimbrial subunit SMF-1"
FT                   /id="PRO_0000432908"
FT   CONFLICT        27..28
FT                   /note="CT -> AA (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   169 AA;  17205 MW;  7515CE18BCDE3FE9 CRC64;
     MLAAAPLAAN AADGTITFNG KVTDKTCTIS TPGGKDFAVN LPTVSKNTLA TAGAVAGRTP
     FAINLTKCSA GNVATYFEPG STVDFNTGRL LNQASANAAT NVQLQLLGSN NQVLPIKAAG
     AGLAQTNSQW VTVGTDGSAD LNYYAEYYAT AAATPGDVTS SVKYTIIYN