SMG7L_ARATH
ID SMG7L_ARATH Reviewed; 880 AA.
AC Q9FZ99; Q84WB4;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Nonsense-mediated mRNA decay factor SMG7-like {ECO:0000250|UniProtKB:Q92540};
DE AltName: Full=Protein SMG7L;
DE AltName: Full=Protetin SMG7-like;
GN Name=SMG7L {ECO:0000312|Araport:AT1G28260}; OrderedLocusNames=At1g28260;
GN ORFNames=F3H9.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=18544632; DOI=10.1242/jcs.027862;
RA Riehs N., Akimcheva S., Puizina J., Bulankova P., Idol R.A., Siroky J.,
RA Schleiffer A., Schweizer D., Shippen D.E., Riha K.;
RT "Arabidopsis SMG7 protein is required for exit from meiosis.";
RL J. Cell Sci. 121:2208-2216(2008).
CC -!- FUNCTION: May play a role in growth and development. {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:18544632}.
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DR EMBL; AC021044; AAF98429.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30937.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30938.1; -; Genomic_DNA.
DR EMBL; BT004036; AAO42070.1; -; mRNA.
DR PIR; G86408; G86408.
DR RefSeq; NP_174147.1; NM_102591.5.
DR RefSeq; NP_973927.1; NM_202198.2.
DR AlphaFoldDB; Q9FZ99; -.
DR SMR; Q9FZ99; -.
DR STRING; 3702.AT1G28260.1; -.
DR iPTMnet; Q9FZ99; -.
DR PaxDb; Q9FZ99; -.
DR PRIDE; Q9FZ99; -.
DR ProteomicsDB; 228448; -.
DR EnsemblPlants; AT1G28260.1; AT1G28260.1; AT1G28260.
DR EnsemblPlants; AT1G28260.2; AT1G28260.2; AT1G28260.
DR GeneID; 839720; -.
DR Gramene; AT1G28260.1; AT1G28260.1; AT1G28260.
DR Gramene; AT1G28260.2; AT1G28260.2; AT1G28260.
DR KEGG; ath:AT1G28260; -.
DR Araport; AT1G28260; -.
DR TAIR; locus:2032205; AT1G28260.
DR eggNOG; KOG2162; Eukaryota.
DR HOGENOM; CLU_303918_0_0_1; -.
DR InParanoid; Q9FZ99; -.
DR OMA; KCQFLCH; -.
DR OrthoDB; 1206578at2759; -.
DR PhylomeDB; Q9FZ99; -.
DR PRO; PR:Q9FZ99; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FZ99; baseline and differential.
DR Genevisible; Q9FZ99; AT.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR019458; Est1_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696; PTHR15696; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..880
FT /note="Nonsense-mediated mRNA decay factor SMG7-like"
FT /id="PRO_0000422381"
FT REPEAT 149..183
FT /note="TPR 1"
FT REPEAT 184..217
FT /note="TPR 2"
FT REGION 669..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 248
FT /note="K -> E (in Ref. 3; AAO42070)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 880 AA; 99784 MW; CDBC1B7AB867CBB2 CRC64;
MEANSADQKQ KPNFLVEVNN IEKQLWTLIH SKTILHTDVS ELYAKAGSTY EQIFKSNLQH
EELQEVEFCL WKLHYKHIDE FRKGLKTNDH AKHMKAFKLF LSKAAEFYQN LISKVRGYYH
RLSEESGEQK SRFLCHRFYI CLGDLQRYQE QYLKAHEHPN WSTAATYYLE AAKSWPDSGN
PHNQLAVLAT YVSDELLALY HCVRSLAVKE PFPGASNNLL LLFEKNRSSP LQSLSTDAEF
NYLNPSEKKV SVKERDLSKA KGELVAGIDL WPLVVRTTSF FFLKSSFDEF GRAFASTIRE
LDAAFAADDR NLEAMLESYQ FMDTARKGPY KILQIVAVFI YIFHNLAEAN GSDIVKEEVK
LTNLALTMVF IVMGRVVERC LKTTPLDSCP LLPALLVFLD YLPFLLDKVE EEEEECRFDE
KSKSAISYFF GKLVDILNQL KVKDKNCPAK TLLALWEDHE LKSLAPLAPI HALLDFSSNM
DLRESFDRGK ELRLQRIISS AIDITTRQKK GSQKWLFFDN QRTHFYTTSG ELQSNGELFH
GNGEGRNRKC VTIGPVEIIP LENERSVPVE EEEVILLKPL VRCQSAPIYS SGIAAKPLSS
DCTTSGNQTT TSNDSLRRTL SLIGSESFSF TQGLKDTDPQ HLHLEEGTVS GRPPSLSAWV
VDKNKEKGRL GLSKPNGLGP IDETGPVSAF DSLSINSSTE HPASSYSPPT PSAPLLPEDA
SWFHNDASTN KAESFYDQTR YMELPGIMKP YTNPPFVGIS SSEWLRRYRE SRNLGPAYSY
QAQGTNNLRN FMAHGSSKFS LLARYGTPND SSQNSTFHPQ LYMEDHESRG EKLGNVQQST
TNPYGFSDDP GPFLRFLREK EWLNENGQRL RGPPPAYMNN
