ID   SMG8_AEDAE              Reviewed;         916 AA.
AC   Q17G65;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=AAEL003157;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       SMG1 and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH477265; EAT45584.1; -; Genomic_DNA.
DR   RefSeq; XP_001656499.1; XM_001656449.1.
DR   AlphaFoldDB; Q17G65; -.
DR   SMR; Q17G65; -.
DR   STRING; 7159.AAEL003157-PA; -.
DR   GeneID; 5577419; -.
DR   KEGG; aag:5577419; -.
DR   VEuPathDB; VectorBase:AAEL003157; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; Q17G65; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; Q17G65; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..916
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378170"
FT   REGION          566..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  103707 MW;  436065CA0BB3E681 CRC64;
     MNPVESFVFP DIPKTIRDVL FKPDKQMIIV GVIGKSSNPT CNKLIGFNLL TTHPALTDSK
     CCEGRIKFYF ENDGNVLYLH FETTFDQQVM AEQLAKAIDT GVQDNFVNFN SYVRSRFARM
     LLFAIQVCHM IVLVEPTSVF DTSYLSIFKS LKIIREKYVL KFLPKLLKAS NVGNYMGKEA
     RLCSPRFIFL FEGTCDIKPE DVEKLEALEC AVEEDIYKML RTEFIITNNS AMSLFSIPRS
     KKFVFFSSDS KAKSDPLLDS IDMLMEYLDK PAAGQQGDKD EEEFMNKLRP CAGYGMSAWS
     VGAGAPKTER ERSVLTLIKK HVAEAFEHGF DDSVSKYRGR SHFAVPGFKS WFEGFKFLHK
     IFIENPDNQN YEPVDVDYKA YLENFHKVID IDERFFADVC EHGMELAMVN YKEMLPHHYS
     GTFHEKKYQQ ARELFLRYAR GPEVEKHELK LKDYCDSIWL NGKQQCEYPS LRGNPCALGK
     HKANDPMDHS SGVVFVSACN CGRTQGHRED PYTIRQANYE FYQLIAKSCS NCTLLERIKF
     PVFEPSSSDF RAAEFINKNL SNLMSLENSN RTPDTGTHPP MTNDHSPHLS GSQKSQDSAS
     NLTFSIDDKE ENETHAKNYA SQGDADEALE QENLNEIVIK VGEHADQTDK EKAILRQPST
     TEYLPGMLHA TSPIGLLPQF PSWSLVCLGP SSIYTHNSGL PEHIQSGFLS GSNFLLPWDV
     SVRLEHAQSW AASYEKIRNR KKNVSQSKSS DSSNNFTLKI FIGIEYECLR GHRFIMSGPD
     TVLRGGSGIV RDSGSKVVFN DMPIYFPCLC RNSNVAQLMR VHIVTPKAPV NVILEPKAKI
     FQNNMQSNFT FTTGQPEPIK LTQSAYWILR LPFVYEGDEG PLMPPSEVNA SNAAMHGILL
     AGMYGIKESE ISEELL