ID   SMG8_CAEBR              Reviewed;         871 AA.
AC   A8WP66;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Suppressor with morphogenetic effect on genitalia protein 8;
GN   Name=smg-8; ORFNames=CBG00981;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       smg-1 and recruited to stalled ribosomes (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; HE600951; CAP22272.1; -; Genomic_DNA.
DR   RefSeq; XP_002629747.1; XM_002629701.1.
DR   AlphaFoldDB; A8WP66; -.
DR   SMR; A8WP66; -.
DR   STRING; 6238.CBG00981; -.
DR   PRIDE; A8WP66; -.
DR   EnsemblMetazoa; CBG00981a.1; CBG00981a.1; WBGene00024282.
DR   GeneID; 8573218; -.
DR   KEGG; cbr:CBG_00981; -.
DR   CTD; 8573218; -.
DR   WormBase; CBG00981a; CBP05876; WBGene00024282; Cbr-smg-8.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_375675_0_0_1; -.
DR   InParanoid; A8WP66; -.
DR   OMA; KGQFLEC; -.
DR   OrthoDB; 645776at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 2.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..871
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378168"
FT   REGION          541..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   871 AA;  100054 MW;  EE2460D512C0C9C2 CRC64;
     MNISEWIEQS RSVFKAQLDT KIKIIGIIGK DYPDHGKGDN INCYLRENVF PVATSDNETC
     TIFAHFSEDE QLLFLVLNGV DDVANLRKCM ESESKNYFEA MAESESQQMR LLHFLFISCH
     FIVIFEQTSR IDLEFIRFLK KVNTLRSLNR RKVSQRLRDV DFDFDSDGRL TVPYVLMAFQ
     RNNIRTDTNI TKKRELYEKL EKNLDHQLTD ILKLYDLTGS GNSALCQLSE SLQVVHLLNP
     DSVKRDIITE MFDIFMAEAE NGNVARVAAN HKLTSNNAFV RFLEDRFRAE KNEISLNIAI
     DMLEALQFVL DGSLEEKPES LRSQTQTFIK RIQSDHMEEA RRLYTNETRP VSGERRGGGF
     RITEQETMDP SVKIRSKQEH LIRFNEATCY IETVVGINQQ EILSQVQTQC NDMWQSDLRA
     CESISMMGHP CVKKVHPTYG DQTVPEARWT AHDASNTLVS TCVCGNKQLV RQEPFTLKEA
     NFDFYEHPDF NCCKGLWRYQ FQLYQEDTEE KDDIMWADRE SNSLRAAKKM AQREDELAVE
     LDDMELPESL QQSYTSSEDS SEDDDDFAIQ TASSEDSLSG SDSYARPGSR RDEFESSKTA
     RDMAVYFAKR IQKLEKLEKM DDFLMGVPNT LTIGKLPMFP SFFLTSLGES NLYKHGAGLK
     NQPNFKLGGE YLTPAVVFLD VDLDVWCRDL VKFRTDDYTR RGTKDLKDDM PRVKLFVGFE
     YECSRGHRFF VDHNGEPLIY PRNVNVLKES SARASLGNIL NADLPLRRPC TCRKPPLKSA
     QLQKIHVVTP KAPVKITIDP KILVPGHEGT YGTGQEPLEL HHSKYYILHL PVVYSGPSGT
     WMPGEYNSER MGTLKGGSIK VVYKPVMPFR W