ID   SMG8_CULQU              Reviewed;         912 AA.
AC   B0W730;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=CPIJ003128;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       SMG1 and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; DS231851; EDS37304.1; -; Genomic_DNA.
DR   RefSeq; XP_001844514.1; XM_001844462.1.
DR   AlphaFoldDB; B0W730; -.
DR   SMR; B0W730; -.
DR   STRING; 7176.CPIJ003128-PA; -.
DR   PRIDE; B0W730; -.
DR   GeneID; 6034156; -.
DR   KEGG; cqu:CpipJ_CPIJ003128; -.
DR   VEuPathDB; VectorBase:CPIJ003128; -.
DR   VEuPathDB; VectorBase:CQUJHB014717; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B0W730; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B0W730; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..912
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378171"
FT   REGION          565..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..623
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  103161 MW;  A977A4A8579346A2 CRC64;
     MNPINSFIFP DIPKDLGKIL MKDDQQLIVV GIIGKSSTPD CNKLVGFNLL TIHPALTDTD
     PRDGRVKFYF ENDGKILYLH FETTFDQHVM ADLLAKAVQT GIQDNFINFN STVRTRFARV
     LLFAIQVCHM IVLVEPSSVF DTSYLSIFKS LKIIREKYVL KFLPKLLKSS NLGNYMGKEA
     RLCSPRFIFF FEGTSNIKPE DVEKLDGLEC SVEEEIYKML RNEFIITNNS AMSLFSIPRS
     KKFVFYNSDK RAKSNPLADS IDLLMKYLNK PAGGQNDDDE DLMSRLRPYD GYGMSAWSVG
     KSKRAEKKER SILALLKEHV AEAFEHGFDD SASKYRGRGH FVIPSFKTWY EGFKLLHKIF
     IDNPSNSSYE TNDPDYKAFL QNFHKIIDID ERFFAEICEH GLELAMVNYK DMLPHHYSST
     FHEKKYEQAH ELFTRYARGP EVERHEQKLK DYCDSIWLNG KQQCEYPSLR GNPCALGKHK
     VKDPTEHSSG VIFVSACNCG RTQGHREDPY TIRQGNYDFY QIIAKSCSSC NVLERVKFPV
     FEPSSNDFRA AEFINKNLSN LMSFEHSNRT PDASTHPPMT NENSPHLSGS QKSQDSASNL
     TFSMDEKRDE ENKSQKFGTQ GEDEDETLEQ ETVNEIVIKV GEHSEDKAIL RQPSTTEYLP
     GMLHAASPAG LLPQFPSWSL VCLGPSSIYT HNSGIPEHVQ SGFLSGANFL LPWDVSVRLE
     HAQSWAASYE KIRNRKKNTS QPKSSESSNT FTLKIFLGVE YECLRGHRFI MSGPDTVLRG
     GSGSIVRDSG SKVVFNDMPI YFPCPCRSSN IAQLMRVHVV TPKAPVNVIV EPKVRILQGT
     TQNCLTFTTG LTEPIKLSQS AYWILRLPFI YEGDSGPLMP PAGVTVANAA THGVLMAGMF
     GIRESEISEE LL